6. You should be able:

1. Classify non-steroidal anti-inflammatory drugs (NSAIDs).

2. Name different groups of drugs which act as anti-inflammatory.

3. What are the adverse effects of NSAIDs.

4. Discuss the choice of NSAIDs on the basis of activity, frequency of administration and suitability.

5. Describe the pharmacology of salicylates.

6. List several synthetic glucocorticoids and the differences between these agents and the naturally occurring hormone.

7. Describe the toxic effects of chronic glucocorticoid therapy.

8. Describe the pharmacokinetics and routes of administration of corticosteroids.

9. How do glucocorticoids act as anti-inflammatory and immunosuppressive agents?

10. Describe the adverse effects observed (i) after abrupt withdrawal and (ii) after prolonged therapy. Also give reasons for producing these adverse effects.

11. Give a comparison of relative anti-inflammatory and salt-retaining properties of commonly used glucocorticoids.

12. Identify the major cytokines and other immunomodulating agents and know their clinical applications.

13. Describe the mechanisms of action, clinical uses, and toxicities of glucocorticoids, cyclosporine, azathioprine, and cyclophosphamide in immunopharmacology.

7. Teaching methods – working in pairs, the prescription writing of drugs for concrete situations; training, defining terms, solving problems, answer questions, working out examples (of the slides, of the handbooks and handouts), MCQs.

7.Literature

1.Katzung B. G., ed. 2003. Basic and Clinical Pharmacology, 9^th ed., Lange Medical Books/McGraw-Hill, Appleton and Lange. PP. 806-848, 903-931.

2.Katzung B.G., Trevor A.J., ed. 1998, Examination & Board Rewiew. 5th ed., Stamford, Connecticut, Appleton & Lange. PP.124-135.

2.Tripathi K.D., ed.1999, Essentials of Medical Pharmacology. 4^th ed., New Delhi, India, Jaypee Brothers. PP.115-147.

3.Sharma V.N., ed.1996 Essentials of Pharmacology. 1th ed., New Delhi, India, CBS Publishers & Distributors. PP.201-209.

8. Assessment - MCQs, ECQs.

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