РГКП «СГМА»		ФОРМА КАЧЕСТВА
		Методические рекомендации для ведения практических занятий
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Приложение № 10

S E M E Y S T A T E M E D I C A L U N I V E R C I T Y

Methodical guidance for classes (practical)

Specialty: General medicine

Discipline: Pharmacology-2

Chair: Pharmacology, Pharmacognosy

Course III

Theme № 1 of Musculoskeletal Pharmacology. Antiinflammatory drugs used for the treatment of joints injury. Peculiarities of the use in children.

Editor: assistant-professor, candidate of medical sciences ______ S.K.Seilkhanov

Semey – 2009

Ratified at the meeting of the chair

Protocol №

the ___ of ______________________ 2009.

The Head of the chair_____________________M.N.Moussin

1. The theme: Antiinflammatory drugs used for the treatment of joints injury. Peculiarities of the use in children.

2. The aim: To introduce to Pharmacology of Antiinflammatory drugs used for the treatment of joints injury.

3. The objectives:

You should know:

Antiinflammatory drugs used for the treatment of joints injury.

You should be able to:

• Describe the effects of aspirin on prostaglandin synthesis.

• List the toxic effects of aspirin.

• Contrast the actions of aspirin and the newer NSAIDs.

• Describe the mechanisms of action of three different drug groups used in gout

• Describe the major naturally occurring glucocorticoid and its actions.

• List several synthetic glucocorticoids and the differences between these agents and the naturally occurring hormone.

• List the indications for the use of corticosteroids in adrenal and nonadrenal disorders.

• Describe the toxic effects of chronic glucocorticoid therapy.

4. The main questions of the theme

1. Describe the processes involved in inflammation

2. List separately the mediators of acute and chronic inflammation.

3. Name different groups of drugs which act as anti-inflammatory.

4. Draw the diagram to illustrate various steps that occur in producing inflammation and bronchospasmdue to disturbance of cell membrane. Also indicate the site of action of anti-inflammatory drugs.

5. Classify non-steroidal anti-inflammatory drugs (NSAIDs). How do they act as anti-inflammatory and analgesic drugs?

6. Describe the pharmacology of saicylates.

7. Describe the main features of the different non-narcotis/analgesic-antipyretic/NSAIDs.

8. Name the various propionic acid derivatives and their formulations and usual anti-inflammatory doses.

9. What are the adverse effects of phenylbutazone?

10. Write notes on Diclofenac, Mefenamic acid, and Piroxicam. What are their advantages and disadvantages?

11. Compare Aspirin and Paracetamol.

12. What are the uses and adverse effect of Indomethacin?

13. Discuss the choice of NSAIDs on the basis of activity, frequency of administration and suitability.

14. What is the aim of therapy in rheumatoid arthritis?

15. Which drugs are useful in arthritic conditions?

16. What is the role of simple analgesics, NSAIDs, and corticosteroids?

17. Discuss the status of gold preparations in rheumatoid arthritis.

18. What is primary and secondary gout?

19. What is the chief abnormality in gout?

20. Is colchicines uricosuric?

21. Describe drugs which are indicated in acute attack of gout.

22. Describe drugs used in chronic gout.

23. Describe the role and mode of action of uric acid synthesis inhibitors.

24. Explain why aspirin and probenecid should not be given simultaneously?

25. How do glucocorticoids act? And what are their metabolic effects on carbohydrate, protein and fat.

26. Describe the pharmacokinetics and routes of administration of corticosteroids.

27. What are the general principles which should be kept in mind regarding the use of corticosteroids?

28. Explain, why abrupt withdrawal of prolonged, high dose corticosteroid therapy is dangerous?

29. Describe the various therapeutic uses of adrenocorticoids and give reasons for their beneficial effect in each condition.

30. How do glucocorticoids act as anti-inflammatory and immunosuppressive agents?

31. Describe the adverse effects observed (i) after abrupt withdrawal and (ii) after prolonged therapy. Also give reasons for producing these adverse effects.

32. What is Cushing’s syndrome? How is its treatment managed?

33. Explain how large doses of adrenocorticosteroids produce (i) osteoporosis, (ii) peptis ulceration (iii) hypertension (iv) glaucoma, (v) myopathy, (vi) behavioral disturbances, (vii) hyperglycemia, (viii) retardation of growth in children.

34. What are the contraindications of adrenocorticosteroids?

35. Give a comparison of relative anti-inflammatory and salt-retaining properties of commonly used glucocorticoids and mineralocorticosteroids. Which among them are not effective on topical application?

36. Write short notes on intraarticular injection of glucocorticoids