1. 

2. *

3. 

4. 

5. 

1. What is the identity of the intermediate (a) and the end-product (b) in the

reaction of ethylenediamine with glyoxal?

1. 

2. *

3. 

4. 

5. 

1. What is the end-product of diethylmalonate condensation with urea?

1. 

2. *

3. 

4. 

5. 

1. Select the mechanism of the following reaction and the position of isoquinolin it will principally occur?

1. 

2. 

3. 

4. *

5. 

1. At what positions of quinoline will the following reaction principally occur?

1. 

2. 

3. *

4. 

5. 

1. What is the product of indigo Blue oxidation with conc. HNO3?

1. indoxyl

2. pyrrole

3. indole

4. *isatin

5. white indigo

1. The condensation of which compounds leads to formation of

polyvinylpirrolidone?

1. furane with ethene

2. pyrrole with ethylene

3. pyrrole with acetylene

4. pyrrolidone with ethylene

5. *pyrrolidone with acetylene

1. Which of the following compound can be used as catalyst in the reactions of Yuriev’s cycle?

1. 

2. 

3. 

4. 

5. *

1. Which of the following compounds will form oxiran when treated with concentrated solution of alkali?

1. 

2. 

3. 

4. 

5. *

1. Which group of alkaloids does theophylline belongs to?

1. isoquinoline and phenanthroisoquinoline alkaloids

2. *purine alkaloids

3. tropane alkaloids

4. pyridine and piperidine alkaloids

5. quinoline alkaloids

1. Choose the correct name for theophylline.

1. 5,7- dimethylxanthine

2. 3,5- dimethylxanthine

3. 2,4- dimethylxanthine

4. 4,6- dimethylxanthine

5. *1,3-dimethylxanthine

1. Choose the most complete definition of alkaloids.

   1. Alkaloids – naturally occurring (plants) oxygencontaining organic compounds.

   2. Alkaloids – naturally occurring (plants and animals) compounds, which display basic properties.

   3. Alkaloids – heterocyclic compounds with one or more hydroxyl-groups.

   4. Alkaloids – nitrogencontaining organic compounds with glycosidic bonds

   5. *Alkaloids – naturally occurring (plants) nitrogencontaining organic compounds, which display basic properties and high level of biological activity.

2. Which of the following reagent can be used to confirm the basic properties of

alkaloids?

1. 

2. 

3. *

4. 

5. 

1. Which of the following reactions result purine?

   1. 

   2. 

   3. 

   4. 

   5. *

2. Which is the identity of the intermediate (A) and the end-product (B) in the following scheme?

1. 

2. 

3. 

4. *

5. 

1. Choose the product of purine reaction with hydrochloric acid?

1. 

2. 

3. *

4. 

5. 

1. For which purine derivative lactam-lactim tautomerism is possible?

   1. 

   2. 

   3. *

   4. 

   5. 

2. Which salt is formed when uric acid react with alkali?

1. 

2. 

3. 

4. *

5. 

1. What reaction can be used to identify uric acid?

1. xanthoprotein test

2. *murexide test

3. indophenine test

4. xanthogenic test

5. isonitrile test

1. Choose the product of the following reaction.

1. 

2. 

3. *

4. 

5. 

1. Which of the following reaction result piperidine?

   1. 

   2. 

   3. 

   4. *

   5. 

2. Which end-product is formed when β -picoline (1) first treated with PCl5, and

then with NH3?

1. picolinic acid amide

2. *nicotinamide (vitamin PP)

3. isonicotinamide

4. ammonium salt of nicotinic acid

5. ammonium salt of isonicotinic acid

1. Select the mechanism of the following reaction and the position of quinoline it will principally occur?

1. 

2. 

3. 

4. *

5. 

1. Which is the end-product of acridine oxidation?

1. 

2. *

3. 

4. 

5. 

1. Which is the end-product of isoquinoline oxidation?

1. *

2. 

3. 

4. 

5. 

1. What is the end-product of the following reaction?

1. 

2. 

3. 

4. *

5. 

1. Choose the proper pair of products of the following reaction.

1. 

2. 

3. 

4. *

5. 

1. Choose the product of the following reaction.

1. 

2. 

3. 

4. *

5. 

1. Which is the end-product of acrolein condensation?

1. 

2. *

3. 

4. 

5. 

1. Which of the following compounds can be used for furan sulfonation?

   1. 

   2. *

   3. 

   4. 

   5. 

2. Which is the product of pyrazole reduction with hydrogen according to the

following scheme?

1. 

2. 

3. 

4. *

5. 

1. Which is the identity of the end-product (4) in the following scheme?

1. 4-nitrofurfural semicarbazone

2. 3-nitrofurfural

3. 5-nitrofurfural diacetate

4. 5-nitrofurfural

5. *5-nitrofurfural semicarbazone

1. Which of the following compounds is indole?

   1. 

   2. 

   3. 

   4. 

   5. *

2. Which reagent can be used to proof the presence of keto-group in isatin

molecule?

1. 

2. 

3. acid fuchsine sulfite

4. 

5. *

1. What is the product of the following reaction?

1. N- methylpyrrole

2. N- acetylpyrrolium chloride

3. b-acetylpyrrole

4. a-acetylpyrrole

5. *N-acetylpyrrole

1. Which is the identity of the intermediate (X) and the end-product (Y) in the

following scheme?

1. 

2. 

3. *

4. 

5. 

1. Choose the correct range of SE reactivity decrease for thiophene, furan, benzene, and pyrrole.

   1. 

   2. 

   3. *

   4. 

   5. 

2. Which of the following heterocycle is acidophobic?

   1. 

   2. 

   3. 

   4. *

   5. 

3. What is the identity of the end-product 2 in the following scheme?

1. 

2. 

3. *

4. 

5. 

1. Which of the following heterocycle is acidophobic?

   1. 

   2. *

   3. 

   4. 

   5. 

2. Which reaction is Yuriev’s cycle reaction?

   1. 

   2. 

   3. 

   4. *

   5. 

3. Which of the following heterocycle is aromatic?

   1. 

   2. *

   3. 

   4. 

   5. 

4. Which type of isomerism is possible for pyrazole and imidazole?

1. nitro-aci-nitro

2. *azole

3. keto-enol

4. amino-imino

5. lactam-lactim

1. Which is the identity of the intermediate (A) and the end-product (B) in the following scheme?

1. 

2. 

3. *

4. 

5. 

1. Choose the correct systematic name of purine.

1. *imidazo[4,5-d] pyrimidine

2. pyrazolo[4,5-d] pyrimidine

3. pyridino[4,5-d]pyrimidine

4. pyrimidino[4,5-d]imidazole

5. pyridazo[4,5-d]pyrimidine

1. What starting compound is required for barbituric acid synthesis?

1. 

2. 

3. 

4. *

5. 

1. Which of the following reactions lead to pyrimidine formation?

1. 

2. 

3. *

4. 

5. 

1. Which of the following reaction is impossible?

   1. 

   2. 

   3. 

   4. *

   5. 

2. Which of the following reactions lead to pyrazine?

   1. 

   2. 

   3. *

   4. 

   5. 

3. Which of the following reaction lead to coumarin formation?

1. 

2. 

3. 

4. *

5. 

1. Which of the following pyrimindine derivative shall undergo the electrophilic substitution reactions?

   1. 

   2. 

   3. 

   4. *

   5. 

2. Choose the correct way for purine atoms numbering.

   1. 

   2. 

   3. 

   4. *

   5. 

3. At what positions of pyridine N-oxide will electrophilic substitution reactions (SE) principally occur?

1. 1, 4

2. 3, 5

3. *2, 4, 6

4. 1, 4, 6

5. 1, 3, 5

1. At what position of pyridine shall electrophilic substitution reactions (SE) principally occur?

1. 6

2. 4

3. *3

4. 2

5. 1

1. At what positions of pyridine will nucleophilic substitution reactions (SN)

principally occur?

1. 3, 5

2. 2, 5

3. 1, 3, 5

4. *2, 4, 6

5. 2, 4, 5

1. Choose the product of the following reaction.

1. 

2. 

3. *

4. 

5. 

1. At what position of pyrazole will reaction with nitric acid (heat) principally

occur?

1. position 5

2. *position 4

3. position 3

4. position 2

5. position 1

1. Choose the structure of analgin.

   1. 

   2. *

   3. 

   4. 

   5. 

2. Which is the identity of the end-product (3) in the following scheme?

1. 

2. *

3. 

4. 

5. 

1. Which reagent shall react with cyclic nitrogen atom of 2-aminothiazole?

1. 

2. 

3. 

4. 

5. *

1. Which is the identity of the end-product (№3) in the following scheme?

1. 

2. 

3. 

4. *

5. 

1. Which is the starting reagent in the synthesis of 5-methyl-1-phenylpyrazolone-5?

1. ethyl acetate

2. diethyl malonate

3. acetic acid

4. *acetoacetic ester

5. ethyl propionate

1. At what position of pyrazole will reaction with CH3I principally occur?

1. position 5

2. position 4

3. position 3

4. *position 2

5. position 1

1. What is the product of imidazole sulfonation?

1. 

2. 

3. *

4. 

5. 

1. Which of the following compound can be used for furane chlorination?

1. 

2. 

3. 

4. 

5. *

1. Which of the following heterocycle is acidophobic?

   1. 

   2. 

   3. *

   4. 

   5. 

2. What is the end-product of reaction of potassium-pyrrolide with iodomethane?

1. α,α’-dimethylpyrrole

2. α,β-dimethylpyrrole

3. β- methylpyrrole

4. *α-methylpyrrole

5. N-methylpyrrole

1. Which statement about furfural is not true?

1. *it forms a-furamide with NH3

2. it forms hydrofuramide with NH3

3. it undergoes Cannizzaro reaction

4. can be obtained from aldopentose

5. it undergoes SE reactions at position 5

1. Which of the following heterocycle is acidophobic?

   1. 

   2. 

   3. 

   4. *

   5. 

2. Which of the following reactions lead to formation of thiophene?

   1. 

   2. 

   3. 

   4. *

   5. 

3. Three- and four-membered heterocycles, such as oxetane, aziridine, and azitidine are:

   1. heterocycles with three heteroatoms

   2. heterocycles with two heteroatoms

   3. aromatic heterocycles

   4. unsaturated heterocycles

   5. *saturated heterocycles

4. Which of the following compounds can be cyclized to aziridine?

1. *

2. 

3. 

4. 

5. 

1. Which reaction characterize aziridine as secondary cyclic amine?

   1. 

   2. 

   3. 

   4. 

   5. *

2. Which reaction does oxiran undergo?

1. electrophilic addition

2. electrophilic substitution

3. nucleophilic substitution

4. free-radical substitution

5. *nucleophilic addition

1. Choose the products of the following reaction.

1. 

2. 

3. *

4. 

5. 

1. Which of the following reaction of oxiran are possible?

   1. 

   2. 

   3. *

   4. 

   5. 

2. Choose the mechanism of the following reaction:

1. 

2. 

3. 

4. *

5. 

1. Heterocyclic compound pyrrole belongs to:

   1. *fivemember heterocycles with one heteroatom

   2. fivemember heterocycles with two heteroatoms

   3. sixmember heterocycles with one heteroatom

   4. fivemember heterocycles with two heteroatoms

   5. condensed heterocycles

2. Heterocyclic compound pyrrole is a part of:

   1. anesthetic means

   2. nucleic acids

   3. preparations for the tuberculosis treatment

   4. bactericide means

   5. *hem of hemoglobin

3. According to the level of saturation heterocyclic compounds are divided on:

   1. condensed and non-condensed

   2. *saturated, unsaturated, aromatic

   3. azoth containing, oxygen containing, sulfur containing

   4. fivemember, sixmember, sevenmember

   5. cycles with one and two heteroatoms

4. According to the nature of heteroatom heterocyclic compounds are divided on:

   1. saturated, unsaturated, aromatic

   2. *nitrogen containing, oxygen containing, sulfur containing

   3. fivemember, sixmember, sevenmember

   4. cycles with one and two heteroatoms

   5. condensed and non-condensed heterocycles

5. 3- and 4-member heterocycles oxethane, azeridine, azetidine are:

   1. *saturated heterocycles

   2. unsaturated heterocycles

   3. aromatic heterocycles

   4. heterocycles with tree heteroatoms

   5. heterocycles with trwo heteroatoms

6. How does pyrrole basic properties change in the comparison with the products of its partial and complete reduction?

   1. does not change

   2. *increases from pyrrole to pyrolidine

   3. increases in the row of pyrolidine, pyroline, pyrrole

   4. decreases in the row of pyroline, pyrolidine, pyrrole

   5. increases in the row of pyrolidine, pyrrole, pyrroline

7. Nitrogen atom in the pyrrole molecule can react with:

   1. *potassium amide

   2. potassium chloride

   3. potassium sulfate

   4. sulfate acid

   5. chloride acid

8. For three- and fourmember heterocycles the following types of reactions are characteristic:

   1. radical substitution

   2. electrophilic and nucleophilic substitution

   3. *electrophilic and nucleophilic accession

   4. radical accession

   5. polymerization

9. According to the size of cycle (total number of atoms in the cycle) heterocyclic compounds can be classified on:

   1. saturated, unsaturated, aromatic

   2. azoth containing, oxygen containing, sulfur containing

   3. *fivemember, sixmember, sevenmember

   4. cycles with one or two heteroatoms

   5. condensed and non-condensed heterocycles

10. To fourmember heterocyclic compounds with one atom of oxygen belongs the following one:

    1. *oxethane

    2. pyrazole

    3. oxyrane

    4. pyrimidine

    5. pyridine

11. To threemember heterocyclic compounds with one atom of oxygen belongs the following one:

    1. pyrimidine

    2. oxethane

    3. *oxyrane

    4. pyrrole

    5. pyridine

12. To fourmember heterocyclic compounds with one atom of sulfur belongs the following one:

    1. thiophene

    2. pyrazole

    3. pyrrole

    4. pyridine

    5. *thiethane

13. To threemember heterocyclic compounds with one atom of sulfur belongs the following one:

    1. thiophene

    2. thiethane

    3. pyrrole

    4. *thiirane

    5. pyridine

14. What compound with concentrated alkali solution will form oxyrane?

    1. *HOCH2—CH2—Cl

    2. HOCH2—CH2—CH2—Cl

    3. H2C=CH2

    4. HOCH2—CH2—OH

    5. H3C—CH3

15. Among of the following compounds choose nitration reagent for the acidophobic compounds:

    1. HNO3 conc

    2. CH3COOH

    3. H3BO3

    4. NaNO2 + HCl

    5. *(CH3CO)2O + HNO3

16. To fivemember heterocyclic compounds with one atom of sulfur belongs the following one:

    1. pyrimidine

    2. pyrazole

    3. pyrrole

    4. *thiophene

    5. pyridine

17. To fivemember heterocyclic compounds with one atom of nitrogen belongs the following one:

    1. pyridine

    2. pyrazole

    3. *indole

    4. furane

    5. pyrimidine

18. Furacilline – medical drug that is used for the treatment of pyoinflammatory processes cased by microorganisms. What heterocycle is a primer compound for furacilline synthesis?

    1. pyrrole

    2. *furan

    3. thiophene

    4. imidazole

    5. pyridine

19. Furfural (2-furylcarbaldehyde) – primer compounf for the synthesis of furacilline, furazolidone and furadonine. Choose reagent that can be used to obtain semicarbazone.

    1. H2N–C6H5

    2. H2N–OH

    3. *H2N–NH–C(O)–NH2

    4. H2N–NH–C(S)–NH2

    5. H2N–NH2

20. 5 – nitrofurfural is a primer compound for the synthesis of furacilline, furazolidone and furadonine. Choose the type of reaction of furfural nitration by conc. nitrate acid in the medium of acetic anhydride?

    1. AN

    2. SR

    3. E

    4. SN

    5. *SE

21. 5 – nitrofurfural is a primer compound for the synthesis of furacilline, furazolidone and furadonine. Choose the mechanism of furfural nitration by conc. nitrate acid in the medium of acetic anhydride?

    1. *radical

    2. ionic

    3. nucleophilic

    4. substitutin by m-position

    5. substitutin by o- and p-position

22. Choose compound, which with 5-nitrofurfural forms furacilline.

    1. *semicarbazide

    2. phenylhydrazide

    3. hydrazine

    4. hydraxylamine

    5. sodium hydrosulfite

23. Nitrogen atom in the pyrrole molecule can react with:

    1. *potassium amide

    2. potassium chloride

    3. potassium sulfate

    4. sulfate acid

    5. chloride acid

24. Choose the more correct name for complete thiophene hydration:

    1. 1,2,3,4,5-pentahydrothiophene

    2. 2,3-dihydrothiphene

    3. 1,2-dihydrothiophene

    4. 3,4-dihydrothiophene

    5. *2,3,4,5-tetrahydrothiophene

25. Which of the following substances can not be sulfonated with concentrated sulfate acid?

    1. thiophene

    2. pyridine

    3. toluene

    4. *pyrrole

    5. naphthalene

26. Which of the following substances has acidophobic properties?

    1. pyridine

    2. pyrazole

    3. *pyrrole

    4. pyrimidine

    5. imidazole

27. Name product of the pyrrole sulfonation:

    1. 3-pyrrole sulfoacid

    2. *2-pyrrole sulfoacid

    3. 4-pyrrole sulfoacid

    4. 5-pyrrole sulfoacid

    5. 1-pyrrole sulfoacid

28. Choose the reagent for furan nitration:

    1. HNO3; H2SO4

    2. HNO3 (dil.)

    3. HNO3 (conc.)

    4. *CH3COONO2

    5. HNO2

29. Pyrrole and furan are sulfonated by:

    1. concentrated sulfate acid

    2. *pyridinesulfotrioxide

    3. diluted sulfate acid

    4. mixture of sulfate and nitrate acids

    5. oleum

30. To fivemember heterocyclic compounds with one atom of nitrogen belongs the following one:

    1. pyrimidine

    2. pyrazole

    3. *pyrrole

    4. furan

    5. pyridine

31. Which of the following reagents will react with pyrrole by heteroatom?

    1. *NaNH2

    2. СН3СОOH

    3. (CH3CO)2O

    4. SnCl4

    5. SO2Cl2

32. Weak acidic properties the following heterocyclic compound has:

    1. pyridine

    2. thiophene

    3. quinoline

    4. furane

    5. *pyrrole

33. To fivemember heterocyclic compounds with one atom of oxygen belongs the following one:

    1. pyrimidine

    2. pyrazole

    3. pyrrole

    4. *furane

    5. pyridine

34. To fivemember heterocyclic compounds with one atom of sulfur belongs the following one:

    1. pyrimidine

    2. *thiphene

    3. pyrrole

    4. pyrazole

    5. pyridine

35. Heterocyclic compound pyrrole belongs to:

    1. *fivemember heterocycles with one heteroatom

    2. fivemember heterocycles with two heteroatoms

    3. sixmember heterocycles with one heteroatom

    4. fivemember heterocycles with two heteroatoms

    5. condensed heterocycles

36. Heterocyclic compound pyrrole is a part of:

    1. anesthetic means

    2. nucleic acids

    3. preparations for the tuberculosis treatment

    4. bactericide means

    5. *hem of hemoglobin

37. What substance will form as a result of interaction of acetoacetic ester with phenylhydrazine?

    1. Amidopyrine

    2. Analgin

    3. Antipyrine

    4. *3-methyl-1-phenylpyrazolone-5

    5. 2,3-dimethyl-1-phenylpyrazolone-5

38. What substance will form as a result of interaction of 4-methylaminoantipyrine with formalin and sodium hydrosulfite?

    1. Amizon

    2. Antipyrine

    3. Aspirin

    4. *Analgin

    5. Amidopyrine

39. 1,3-diazol is isomer of:

    1. Indole

    2. Benzimidazole

    3. *Pyrazole

    4. Pyrole

    5. Pyridine

40. 1,2-diazole is isomer of:

    1. Indole

    2. Benzimidazole

    3. *Imidazole

    4. Pyrole

    5. Pyridine

41. Oxazole is isomer of:

    1. Azole

    2. Thiazole

    3. Furan

    4. *Isooxazole

    5. Pyrrole

42. Which of the following heterocycles does belong to azoles?

    1. Indole

    2. *Thiazole

    3. Thiophene

    4. Pyrrole

    5. Furan

43. Which of the following heterocycles has basic properties?

    1. *Pyrazole

    2. tetrahydrofurane

    3. Thiophene

    4. Pyrolidine

    5. Pyrroel

44. What heterocycle is in the content of vitamin В1 (thiamin)?

    1. Thiophene

    2. Pyridine

    3. *Thiazole

    4. Oxazole

    5. Purine

45. Which of the following medical compounds does contain imidazole heterocycle?

    1. analgin

    2. *histidine

    3. antipyrine

    4. amidopyrine

    5. furacilline

46. If oxazole cycle is activated by electronodonor subtitution the reactions of SE takes place. Specify the position, by which this reaction will go:

    1. 3 and 2

    2. 2 and 5

    3. *4 and 5

    4. 3 and 4

    5. 2 and 1

47. What reaction does case pyrazole formation?

    1. Intramolecular dehydration of ethanol

    2. Melting with alkali solution of benzolsulfoacid

    3. Cyclotrimerization of acetylene

    4. Pentose dehydratation

    5. *Accession of diazoalkanes to acetylenes

48. What reaction does case pyrazole formation?

    1. Intramolecular dehydration of ethanol

    2. Melting with alkali solution of benzolsulfoacid

    3. Cyclotrimerization of acetylene

    4. Pentose dehydratation

    5. *Interaction of hydrazine with pentadione-2,4

49. Pyrazole according to its physical properties is:

    1. Crystalline orange compound

    2. Liquid, good soluble in water

    3. Gaseous substance

    4. *Colorless crystalline compound, good soluble in water

    5. Liquid, insoluble in water

50. Alkylation and acylation of pyrazole conduct with formation of the following products:

    1. *N–substitution

    2. m–substitution

    3. p–substitution

    4. o- and p-substitution

    5. Mixture of N- and m-substituution

51. Choose the product of pyrazole reduction:

    1. Pyridine

    2. Hydropyrazole

    3. *Pyrazoline–2

    4. Pyrazolidine

    5. Pyrrole

52. Choose the product of pyrazole partial reduction:

    1. Pyridine

    2. *3,4-dihydropyrazole

    3. Hydropyrazole

    4. 1-,2-dihydropyrazole

    5. Trihydropyrazole

53. Choose the product of pyrazole complete reduction:

    1. Pyridine

    2. Dihydropyrrole

    3. Trihydropyrazole

    4. Pyrrole

    5. *Pyrazolidine

54. Choose the product of pyrazole complete reduction:

    1. Pyridine

    2. *Tetrahydropyrazole

    3. 3,4-dihydropyrazole

    4. Trihydropyrazole

    5. Pyrrole

55. Choose reagent for pyrazole partial reduction:

    1. CH3COOH

    2. C2H5OH

    3. 2H2(Pt)

    4. *2H(C2H5OH+Na)

    5. KMnO4

56. Choose reagent for pyrazole complete reduction:

    1. CH3COOH

    2. 2H(C2H5OH+N

    3. *2H2(Pt)

    4. C2H5OH

    5. KMnO4

57. Choose chemical name for antipyrine:

    1. 4-nitrozoantipyrine

    2. *2,3-dimethyl-1-phenylpyrazolone-5

    3. 3-methyl-1-phenylpyrazolone-5

    4. 2,3-dimethyl-4-dimethylamino-1-phenylpyrazolone-5

    5. sodium 2,3-dimethyl-4-dimethylamino-1-phenylpyrazolone-5-N-methanesulfonate

58. Choose chemical name for amidopyrine:

    1. 4-nitrozoantipyrine

    2. 2,3-dimethyl-1-phenylpyrazolone-5

    3. 3-methyl-1-phenylpyrazolone-5

    4. *2,3-dimethyl-4-dimethylamino-1-phenylpyrazolone-5

    5. sodium 2,3-dimethyl-4-dimethylamino-1-phenylpyrazolone-5-N-methanesulfonate

59. Choose chemical name for analgin:

    1. 4-nitrozoantipyrine

    2. 2,3-dimethyl-1-phenylpyrazolone-5

    3. 3-methyl-1-phenylpyrazolone-5

    4. 2,3-dimethyl-4-dimethylamino-1-phenylpyrazolone-5

    5. *sodium 2,3-dimethyl-4-dimethylamino-1-phenylpyrazolone-5-N-methanesulfonate

60. Choose chemical name for sodium methamizole:

    1. 4-nitrozoantipyrine

    2. 2,3-dimethyl-1-phenylpyrazolone-5

    3. 3-methyl-1-phenylpyrazolone-5

    4. 2,3-dimethyl-4-dimethylamino-1-phenylpyrazolone-5

    5. *sodium 2,3-dimethyl-4-dimethylamino-1-phenylpyrazolone-5-N-methanesulfonate

61. Choose correct name of the preparation with the chemical name 2,3-dimethyl-1-phenylpyrazolone-5:

    1. *Antipyrine

    2. Aspartic acid

    3. Aspirin

    4. Amidopyrine

    5. Analgin

62. Choose correct name of the preparation with the chemical name 2,3-dimethyl-4-dimethylamino-1-phenylpyrazolone-5:

    1. Antipyrine

    2. Aspartic acid

    3. Aspirin

    4. *Amidopyrine

    5. Analgin

63. Choose correct name of the preparation with the chemical name sodium 2,3-dimethyl-4-dimethylamino-1-phenylpyrazolone-5-N-methanesulfonate:

    1. Antipyrine

    2. Aspartic acid

    3. *Analgin

    4. Amidopyrine

    5. Aspirin

64. Choose correct name of the preparation with the chemical name sodium 2,3-dimethyl-4-dimethylamino-1-phenylpyrazolone-5-N-methanesulfonate:

    1. *Sodium methamizole

    2. Aspartic acid

    3. Aspirin

    4. Amidopyrine

    5. Antipyrine

65. Analgin is used in the medical practice as:

    1. Form of vitamin PP

    2. Antibacterial mean

    3. *Analgesic mean

    4. Vasodilator

    5. Drug against tuberculosis

66. For imidazole obtaining use interaction of the following compounds:

    1. Acetoacetic ester and phenylhydrazine

    2. *Glyoxal, ammonia, formaldehyde

    3. Ethanol and alkali

    4. Ethanoic acid and ethyl alcohol

    5. Acetylene and ammonium

67. Imidazole is:

    1. Crystalline yellow compound

    2. Liquid, insoluble in water

    3. *Colorless crystalline compound, good soluble in water

    4. Gaseous compound

    5. Liquid with sharp smell

68. To the imidazole derivatives the following compound belongs:

    1. *Histidine

    2. Vitamin PP

    3. Furfural

    4. Norsulfazole

    5. Cordiamine

69. To the imidazole derivatives the following compound belongs:

    1. Vitamine PP

    2. Norsulfazole

    3. Furfural

    4. *Histamine

    5. Cordiamine

70. To the imidazole derivatives the following compound belongs:

    1. Vitamine PP

    2. *Pilocarpine

    3. Furfural

    4. Norsulfazole

    5. Cordiamine

71. Benzimidazole can be obtained by the interaction of:

    1. *О-phenylenediamine with formic acid;

    2. Acetylene with ammonia

    3. Ethanoic acid and ethanol

    4. Glyoxal, ammonia, formaldehyde

    5. Acetoacetic ester and phenylhydrazine

72. Benzimidazole has:

    1. Oxidative properties

    2. Reductive properties

    3. Acidic properties

    4. *Amphoteric properties

    5. Basic properties

73. Benzimidazole cycle is a part of vitamin:

    1. *В12;

    2. С;

    3. А;

    4. Н;

    5. РР.

74. Benzimidazole cycle is a part of the following drug:

    1. Analgin

    2. *Dibazole

    3. Norsulfazole

    4. Phthalazol

    5. Furacilline

75. Thiazole is a part of the following natural compound:

    1. *Vitamin В1

    2. Vitamin С

    3. Vitamin А

    4. Vitamin РР

    5. Vitamin Н

76. Thiazole is a part of the following natural compound:

    1. Vitamin РР

    2. Vitamin Н

    3. *Penicillin

    4. D–carotene

    5. itamin С

77. Thiazole is a part of the following medical drug:

    1. Isoniazide

    2. Phenobarbital

    3. Cordiamine

    4. *Norsulfazole

    5. Furacilline

78. Thiazole is a part of the following medical drug:

    1. Isoniazide

    2. Phenobarbital

    3. Cordiamine

    4. *Phthalazol

    5. Furacilline

79. A thizole nucleus is a part of natural penicillins. The drug has:

    1. Analgesic properties

    2. *Antimicrobial properties

    3. Vasodilatation activity

    4. Bronchodilatation activity

    5. Antituberculosis properties

80. By the presence of free pare of electrons of pyridine type nitrogen atom oxazole has the following properties:

    1. *Weak basic properties

    2. Strong basic properties

    3. Weak acidic properties

    4. Strong acidic properties

    5. Amphoteric properties

81. Isooxazole has the following properties:

    1. Amphoteric

    2. Strong acidic

    3. Weak acidic

    4. Strong basic

    5. *Weak basic

82. Qualitative reaction on antipyrine is reaction with:

    1. H2

    2. HCl

    3. NH3

    4. CH3OH

    5. *FeCl3

83. Qualitative reaction on antipyrine is intereaction with:

    1. H2

    2. *NaNO2(H+)

    3. NH3

    4. CH3OH

    5. HCl

84. Qualitative reaction on antipyrine is reaction with FeCl3. As a result complex salt (ferropyrine) will form. What is the color of this complex?

    1. Red

    2. Yellow

    3. Brown

    4. *Orange

    5. Blue

85. Qualitative reaction on antipyrine is reaction with FeCl3. As a result orange color complex salt will form. This is:

    1. *Ferropyrine

    2. Furazolidone

    3. Furadonine

    4. Furfural

    5. Furacilline

86. Qualitative reaction on antipyrine is reaction with NaNO2(H+). As a result 4–nitrozoantipyrine will form. This compound has the following color:

    1. Colorless

    2. Orange

    3. Blue

    4. Yellow

    5. *Emerald-green color

87. Qualitative reaction on antipyrine is reaction with NaNO2(H+). As a result emerald-green compound will form. This is:

    1. 3–aminoantipyrine

    2. Amidoantipyrine

    3. 4–aminoantipyrine

    4. 2–nitrozoantipyrine

    5. *4–nitrozoantipyrine

88. Qualitative reaction on amidopyrine is intereaction with:

    1. H2

    2. *FeCl3 (Н+)

    3. CH3OH

    4. H2SO4

    5. HCl

89. Qualitative reaction on anmidopyrine is intereaction with:

    1. H2

    2. *К3[Fe(СN)6] and Fe3+

    3. CH3OH

    4. H2SO4

    5. HCl

90. Choose the reaction that can be used to distinguish analgin from amidopyrine:

    1. H2

    2. H2SO4

    3. NaNO2

    4. *FeCl3 (Н+)

    5. HCl,t

91. Choose the reaction that can be used to distinguish analgin from amidopyrine:

    1. H2

    2. H2SO4

    3. NaNO2

    4. *К3[Fe(СN)6] Fe3+

    5. HCl,t

92. As a result of interaction of amidopyrine with К3[Fe(СN)6], in the presence of FeCl3 blue color complex will form with the following content:

    1. Fe[Fe(СN)6]

    2. *Fe4[Fe(СN)6]3

    3. К4[Fe(СN)6]

    4. КFe[Fe(СN)6]

    5. К2Fe[Fe(СN)6]

93. To the preparation, which is a derivative of pyrazolone-5, solution of FeCl3 is added. Observe the appearance of the intense orange coloration. Choose this preparation:

    1. Penicilline

    2. Anesthesin

    3. Amidopyrine

    4. *Antipyrine

    5. Analgine

94. As a result of antipyrine nitrozation with the following reduction the next compound will form:

    1. *4-nitrozoantipyrine

    2. 2-aminoantipyrine

    3. Amidopyrine

    4. 3-aminoantipyrine

    5. 4-aminoantipyrine

95. As a result of 4-aminoantupyrine methylation the following compound will form:

    1. *Amidopyrine

    2. 3-methyl-1-phenylpyrazolone-5

    3. 2,3-dimethyl-1-phenylpyrazolone-5

    4. 4-nitrozoantipyrine

    5. Analgin

96. Why quinoline and isoquinoline give reactions of eletrophilic substitution previously by the positions 5 and 8?

    1. nitrogen atom has bigger electronegativity than carbon atom

    2. *positions 5 and 8 have bigger electronic density

    3. nitrogen atom has sp2 –hybridization of the electronic

    4. benzene cycle has three double bounds

    5. nucleophilic substitution reactions are not possible

97. For pyridine reactions of electrophilic (SE) nucleophilic (SN) substitution are characteristic. Lower reaction ability of pyridine in the reactions of SE is caused by:

    1. size of the cycle

    2. aromatic character of the pyridine cycle

    3. basic properties

    4. carbon atom hybridization атомів вуглецю

    5. *electron acceptor properties of nitrogen atom

98. How many π-electrons do form aromatic system of pyridine?

    1. 14

    2. 10

    3. *6

    4. 8

    5. 12

99. Choose the mechanism of pyridine hydroxylation in position 2:

    1. *SN

    2. SE

    3. AE

    4. SR

    5. AN

100. Point the mechanism of the 2-aminopyridine formation by Chichibabin:

     1. AR

     2. SE

     3. AE

     4. SN

     5. *SR

101. Choose the way of piperidine from pyridine obtaining in one stage:

     1. pyridine amination

     2. pyridine nitration

     3. pyridine methylation

     4. *pyridine hydration

     5. pyridine interaction with hydrochloric acid

102. For pyridine the following reactions are characteristic:

     1. electrophilic accession andта electrophilic substitution

     2. *electrophilic and nucleophilic substitution

     3. nucleophilic accession and nucleophilic substitution

     4. nucleophilic substitution and elimination

     5. radical substitution and electrophilic accession

103. Pyridine – aromatic heterocycle, which is a part of many medical drugs. Determine how many monomethyl substituted pyridines exist.

     1. 1

     2. 2

     3. *3

     4. 4

     5. 5

104. According to the Hukel rule quantity of π-electrons in the aromatic system can be determined by the following formula 4n+2. What number of π-electrones does acridine molecule contain?

     1. 10

     2. *14

     3. 8

     4. 6

     5. 12

105. Nitrogen atom in the pyridine molecule can react with:

     1. *hydrochloric acid

     2. potassium hydroxyde

     3. calcium oxide

     4. potassium carbonate

     5. potassium amide

106. Nicotinic acid amide (vitamin РР) is the derivative of:

     1. pyrazole

     2. thiphene

     3. pyrrole

     4. furan

     5. *pyridine

107. Acridine gives reactions of electrophilic substitution previously by the position:

     1. 2 and 3

     2. *2

     3. 5

     4. 5 and 8

     5. 2 and 7

108. Reactions of electrophilic and nucleophilic substitution in the quinoline nuclei go in the following positions:

     1. SE in position 5, SN – in position 4

     2. SE in position 2, SN – in position 4

     3. SE in position 3, SN – in positions 2 and 4

     4. *SE in positions 5 and 8, SN – in position 2

     5. SE in position 6, SN – in positions 3 and 4

109. After the nicotine oxidation in the hard conditions the following compound will form:

     1. pyridine-3,4-dicarboxylic acid

     2. pyridine-2-carboxylic acid

     3. pyridine-4-carboxylic acid

     4. pyridine-2,3-dicarboxylic acid

     5. *pyridine-3-carboxylic acid

110. Derivatives of cyclic and heterocyclic compounds are the structural fragment of the many medical drugs. Which of the following compounds does not have carbon atom in sp2 – hybridized state?

     1. *piperidine

     2. pyridine

     3. pyrrole

     4. pyroline

     5. pyridazine

111. Which of the following acids is pro-vitamin РР?

     1. pycolinic

     2. isonicotinic

     3. *nicotinic

     4. salicylic

     5. anthranilic

112. Which of the following compounds after the oxidation will form nicotinic acid?

     1. pyrazine

     2. *β-pycoline

     3. γ-pycoline

     4. propylene glycol

     5. α-pyrone

113. Which of the following cycles is a structural fragment of alkaloid lobeline, anabazine, is a part of analgesic mean promedol?

     1. *piperidine

     2. piperazine

     3. pyrimidine

     4. pyridazine

     5. pyridine

114. Pyrimidine is an aromatic heterocyclic compound; its derivatives are in the content of nucleic acids, vitamins, antibiotics, medical drugs. Enter the number of electrons involved in the formation of the closed conjugated system and corresponded to the Huckel’s rule.

     1. *6

     2. 14

     3. 10

     4. 26

     5. 18

115. Pyrimidine is an aromatic heterocyclic compound. Determine the number of electrons that take part in the formation of aromatic system of the pyrimidine molecule:

     1. 2

     2. 4

     3. *6

     4. 8

     5. 10

116. Barbituric acid is one of the most important pyrimidine derivatives. What type of tautomery is characteristic for barbituric acid?

     1. Azol and nitro-acy-nitro tautomery

     2. Keto-enol and nitro-acy-nitro tautomery

     3. Lactam-lactim and nitro-acy-nitro tautomery

     4. *Keto-enol and lactam-lactim

     5. Cyclic-chain and nitro-acy-nitro tautomery

117. Pyrazole – aromatic heterocycle. Determine the product of pyrazole interaction with conc. НNO3 at the heating:

     1. 3-Nitropyrazole

     2. *4-Nitropyrazole

     3. Pyrazolyl nitrate

     4. 5-Nitropyrazole

     5. 3,5-Dinitropyrazole

118. Barbituric acid is in the base of some medical preparations. What heterocycle is in the base of barbituric acid?

     1. *Pyrimidine

     2. Pyrazine

     3. Pyridazine

     4. Pyridine

     5. Insole

119. Point the type of tautomery of pyramiding foundations – thymine, uracil, and cytosine:

     1. azol

     2. nitro-acy-nitro

     3. keto-enol

     4. thion-thiol

     5. *Lactam-lactim

120. Derivatives of which heterocycle has azol tautomery?

     1. pyridazine

     2. pyrazine

     3. *pyrazole

     4. thiazole

     5. oxazole

121. What reaction can be used to obtain pyridazine?

     1. Condensation of malondialdehyde with hydrazine

     2. *Condensation of maleinedialdehyde with hydrazine

     3. Condensation of acetaldehyde with ammonia

     4. Condensation of ethylenediamine with glyoxal

     5. Diethylmalonate interaction with urea

122. Choose heterocycle that is in the base of barbituric acid, which derivatives are used in the medicine as medical drugs and have hypnotic and anticonvulsion action.

     1. pyridine

     2. pyridazine

     3. pyrazine

     4. piperidine

     5. *pyrimidine

123. Sixmember azotcontaining heterocyclic compounds have basic properties. Specify the compound, which has the biggest basic properties.

     1. Pyrazine

     2. Pyridine

     3. Pyrimidine

     4. *Piperazine

     5. Pyridazine

124. To the sixmember heterocycles with two nitrogen heteroatoms the following compound belongs:

     1. Pyrrolidine

     2. Purine

     3. *Pyrimidine

     4. Pyrrole

     5. Pyridine

125. Choose the compound, which derivatives are used in the medicine as hypnotic means:

     1. Pyridine

     2. Nicotinic acid

     3. Xanthine

     4. Uric acid

     5. *Barbituric acid

126. Derivatives of barbituric acid are used in the medical practice as:

     1. Antipyretic means

     2. Antiseptic means

     3. Antibiotics

     4. *Hypnotic means

     5. Preparations with anti-mycosis action

127. For diazines is cheracteristic:

     1. The high reactivity in the reactions of Е

     2. Low reactivity in the reactions of SN

     3. The high reactivity in the reactions of SR

     4. The high reactivity in the reactions of SЕ and SN

     5. *The high reactivity in the reactions of SN and low reactivity in the reactions of SЕ

128. What compound can be obtained by the interaction of maleinealdehyde with hydrazine?

     1. Pyrrole

     2. *Pyridazine

     3. Pyrimidine

     4. Pyrazine

     5. Pyridine

129. Pyridazine is:

     1. *A weak base

     2. An inert compound

     3. A strong base

     4. A weak acid

     5. a strong oxidant

130. What compound will form after the pyridazine interaction with HCl?

     1. 5-chloropyridazine

     2. 3-chloropyridazine

     3. *pyridazinium chloride

     4. pyrimidinium chloride

     5. pyrazinium chloride

131. What compound will form after the pyridazine interaction with CH3I?

     1. 6-methylpyridazine iodide

     2. *N-methylpyridazine iodide

     3. 3-methylpyridazine iodide

     4. 4-methylpyridazine iodide

     5. 5-methylpyridazine iodide

132. Under the action of peroxyacid (CH3COOOH) pyridazine oxidizes with formation of:

     1. *pyridazine N-oxide

     2. pyrimidine N-oxide

     3. pyrazine N-oxide

     4. pyridazinone-4

     5. pyridazinone-5

133. At the pyridazine reduction by sodium in alcohol solution the following compound will form:

     1. Butylamine

     2. Diethylamine

     3. Piperidine

     4. *Tetramethylenediamine

     5. Pyrimidine

134. Choose the chemical name of pyrimidine:

     1. 1,5-diazine

     2. diazepine

     3. 1,4-diazine

     4. 1, 2-diazine

     5. *1,3 -diazine

135. Choose the mechanism of the reaction of the pyrazine interaction with sodium amide:

     1. SE

     2. SR

     3. *SN

     4. E

     5. AN

136. The reaction of the pyrazine interaction with sodium amide will go in the following position:

     1. 5

     2. *2

     3. 1

     4. 3

     5. 4

137. Under the action of peroxyacids pyrazine oxidizes with formation of:

     1. *Pyrazine mono-N-oxide

     2. Pyrazone-2

     3. Pyrazine di-N,N-oxide

     4. Pyrazone-3

     5. Pyrazone-5

138. Choose the product of pyrazine reduction by sodium in ethanol:

     1. Pyrrole

     2. *Piperazine

     3. Pyrimidine

     4. Pyridazine

     5. Pyridine

139. Choose systematic name of phenothiazine:

     1. Dibenzo-1,4-thiophene

     2. Benzo-2-thiazole

     3. Benzo-1-thiazole

     4. *Dibenzo-1,4-thiazine

     5. Dibenzo-1,5-thiazine

140. What products will form after the phenothiazine interaction with iodomethane?

     1. 7-methyl derivatives

     2. *N-methyl derivatives

     3. S-methyl derivatives

     4. 2-methyl derivatives

     5. 5-methyl derivatives

141. What products will form after the phenothiazine interaction with chloroanhydride of acetic acid?

     1. S-acetyl derivatives

     2. S-methyl derivatives

     3. N-methyl derivatives

     4. *N-acetyl derivatives

     5. N-chloroderivatives

142. Oxidation of phenothiazine goes by:

     1. *S atom

     2. N atom

     3. С2 atom

     4. С4 atom

     5. С6 atom

143. Which of the following preparations does include phenothiazine nuclei?

     1. Phthivazide

     2. Furacylline

     3. Cordiamine

     4. *Aminazine

     5. Vitamin РР

144. What gas will evaporates after the melting of barbituric acids with NaOH:

     1. SO3

     2. CO

     3. SO2

     4. NO2

     5. *NH3

145. After the barbiturates interaction with NaOH solution forms:

     1. Black precipitate

     2. White precipitate

     3. *Mono- and disodium salts

     4. NH3

     5. Gas CO2

146. After the adding of an excess of AgNO3 to the barbital sodium salt will form:

     1. Gas NH3

     2. White precipitate of disilver salt

     3. *Yellow precipitate of disilver salt

     4. Gas СО

     5. Black precipitate of Ag

147. Barbituric acid can exist in these two forms:

     1. Acy- and nitro-

     2. *Oxo- and hydroxy-

     3. Lactim and lactam

     4. Cyclo- and oxo-

     5. Keto- and enol

148. For its physical properties pyrimidine is:

     1. Gaseous substance

     2. Liquid, insoluble in water

     3. A black crystalline substance

     4. Yellow liquid

     5. *Colorless crystalline substance, easily soluble in water

149. Pyrimidine molecule in the reactions with mineral acids forming salts of:

     1. Complex compounds

     2. *With the participation of one nitrogen atom

     3. Involving two nitrogen atoms

     4. Acidic salts

     5. Basic salts

150. Electronodonor substituents in the pyrimidine nuclei:

     1. Promote the passage of the АN reactions

     2. Promote the passage of the АЕ reactions

     3. *Promote the passage of the SЕ reactions

     4. Promote the passage of the SN reactions

     5. Promote the passage of the Е reactions

151. Nitration of the pyrimidine derivative (SЕ) is conducted with the following reagent:

     1. *HNO3(conc.), H2SO4(conc.)

     2. CH3COONO2

     3. HNO3(dil.)

     4. NO2, H2SO4(conc.)

     5. N2, H2SO4(conc.)

152. Sulfonation of the pyrimidine derivative (SЕ) is conducted with the following reagent:

     1. SO3

     2. *H2SO4 (conc.)

     3. SO2

     4. C6H5SO3H

     5. S

153. Halogenation of the pyrimidine derivative (SЕ) is conducted with the following reagent:

     1. HClO3

     2. HBrO

     3. *Br2(AlCl3)

     4. HBr

     5. HCl

154. Choose the positions in the pyrimidine molecule for SN reactions:

     1. 2,5,6

     2. 1,4,6

     3. *2,4,6

     4. 2,3,5

     5. 1,2,3

155. Choose the mechanism of the pyrimidine interaction with NaNH2:

     1. АЕ

     2. АN

     3. Е

     4. SE

     5. *SN

156. Reaction of pyrimidine interaction with HNО3 (conc.) in the presence of H2SO4 (conc.) will go by the following mechanism:

     1. АЕ

     2. SR

     3. SN

     4. *SE

     5. E

157. Interaction of pyrimidine derivative with Br2 in the presence of H2SO4 (conc.) will go by the following mechanism:

     1. АЕ

     2. SR

     3. SN

     4. *SE

     5. E

158. Barbiturates - 5,5-disubstituted barbituric acid derivatives show:

     1. *Hypnotic and antispasmodic action

     2. Analgesic effect

     3. Antituberculosis action

     4. Expectorant action

     5. Hemostatic effect

159. Barbital - 5,5-disubstituted barbituric acid derivative. R and R’ are:

     1. *C2H5, C2H5

     2. CH3, CH3

     3. C2H5, iso-C5H11

     4. CH3, C6H5

     5. C6H5, C2H5

160. Phenobarbital - 5,5-disubstituted barbituric acid derivative. R and R’ are:

     1. C2H5, C2H5

     2. CH3, CH3

     3. C2H5, iso-C5H11

     4. CH3, C6H5

     5. *C6H5, C2H5

161. Barbamil - 5,5-disubstituted barbituric acid derivative. R and R’ are:

     1. C2H5, C2H5

     2. CH3, CH3

     3. *C2H5, iso-C5H11

     4. CH3, C6H5

     5. C6H5, C2H5

162. To the pyrimidine bases the following compound belongs:

     1. Pteridine

     2. Guanine

     3. Purine

     4. *Thymine

     5. Adenine

163. The pyrimidine bases the following compound belongs:

     1. Pteridine

     2. Guanine

     3. Purine

     4. *Uracil

     5. Adenine

164. To the pyrimidine bases the following compound belongs:

     1. Pteridine

     2. Guanine

     3. Purine

     4. *Cytosine

     5. Adenine

165. Uracil is a part of:

     1. Phthalazol

     2. *Nucleic acid

     3. Aminoacid

     4. Barbiturates

     5. Norsulfazolum

166. Thymine is a part of:

     1. Phthalazol

     2. *Nucleic acid

     3. Aminoacid

     4. Barbiturates

     5. Norsulfazolum

167. Cytosine is a part of:

     1. Phthalazol

     2. *Nucleic acid

     3. Aminoacid

     4. Barbiturates

     5. Norsulfazolum

168. For uracil is characteristic the following type of tautomery:

     1. *Lactim-lactam tautomery

     2. Acy-nitro tautomery

     3. Cyclo-oxo tautomery

     4. Keto-enol tautomery

     5. Oxo-hydroxy tautomery

169. For cytosine is characteristic the following type of tautomery:

     1. *Lactim-lactam tautomery

     2. Acy-nitro tautomery

     3. Cyclo-oxo tautomery

     4. Keto-enol tautomery

     5. Oxo-hydroxy tautomery

170. For thymine is characteristic the following type of tautomery:

     1. *Lactim-lactam tautomery

     2. Acy-nitro tautomery

     3. Cyclo-oxo tautomery

     4. Keto-enol tautomery

     5. Oxo-hydroxy tautomery

171. What compound does include pyrimidine cycle?

     1. Vitamin РР

     2. Vitamin Н

     3. Vitamin С

     4. Vitamin А

     5. *Vitamin В1

172. Which of the following alkaloids does not have optical activity?

     1. Nicotine

     2. *Caffeine

     3. Anabasine

     4. Lobeline

     5. Quinine

173. Which of the following alkaloids does not have optical activity?

     1. *Theophylline

     2. Nicotine

     3. Lobeline

     4. Anabasine

     5. Quinine

174. Which of the following alkaloids does not have optical activity?

     1. Nicotine

     2. Lobeline

     3. Anabasine

     4. Quinine

     5. *Theobromine

175. Which of the following alkaloids does not have optical activity?

     1. Anabasine

     2. Nicotine

     3. *Papaverine

     4. Quinine

     5. Lobeline

176. Which of the following alkaloids does not have optical activity?

     1. Lobeline

     2. Nicotine

     3. Anabasine

     4. *Codeine

     5. Quinine

177. Which of the following alkaloids does not have optical activity?

     1. Nicotine

     2. *Scopolamine

     3. Anabasine

     4. Lobeline

     5. Quinine

178. Which of the following alkaloids does not have optical activity?

     1. *Cocaine

     2. Anabasine

     3. Nicotine

     4. Quinine

     5. Lobeline

179. Which of the following alkaloids does not have optical activity?

     1. Quinine

     2. Nicotine

     3. Lobeline

     4. Anabasine

     5. *Reserpine

180. Which of the following alkaloids does not have optical activity?

     1. Nicotine

     2. Anabasine

     3. Quinine

     4. *Strychnine

     5. Lobeline

181. Which of the following reagents can be used to show basic properties of alkaloids?

     1. NH4OH

     2. HNO2

     3. *HCl

     4. NaOH

     5. NaCl

182. Uric acid belongs to:

     1. *Dibasis, triatomic acids

     2. Onebasic diatomic acids

     3. Tribasic, oneatomic acids

     4. Dibasic, diatomic acids

     5. Tribasic, triatomic acids

183. Atropine - belladonna alkaloid. Determine reagent that can be used to identify primary alcoholic group in the atropine molecule:

     1. *K2Cr2O7 (H+)

     2. HNO3

     3. H2SO4

     4. FeCl3

     5. Ag(NH3) 2OH

184. Which of the following heterocycles is the base of uric acid?

     1. *Purine

     2. Indole

     3. Pyrimidine

     4. Imidazole

     5. Pyridine

185. Adenine, guanine, xanthine and hypoxantine are purine derivatives. How many and what heteroatoms are in the primer structure of these compounds?

     1. *four nitrogen atoms

     2. one nitrogen atom and three oxygen atoms

     3. two nitrogen atoms and two oxygen atoms

     4. three nitrogen atoms and one oxygen atom

     5. nothing

186. Morphine – alkaloid of isoquinoline and phenanthrene isoquinoline group. At the interaction with FeCl3 solution gives blue color. This reaction is qualitative on:

     1. Primary amino-group

     2. *Phenol hydroxyl

     3. Aldehyde group

     4. Secondary nitrogroup

     5. α-diol fragment

187. A purine nucleus is the main structural fragment of caffeine, theophylline, theobromine, adenine, guanine and uric acid, which have higher physiological activity. Purine is an aromatic heterocycle. Determine the number of ?-electrons that take part in the formation of aromatic system.

     1. *10

     2. 6

     3. 14

     4. 18

     5. 26

188. The most used method for alkaloids extraction is the following one:

     1. Filtration

     2. *Extraction

     3. Sublimation

     4. Recrystallization

     5. Distillation

189. Extraction in the form of salts is one of the methods of alkaloids elimination. In this case raw materials are processed by:

     1. Hexane

     2. Formalin

     3. Carbon tetrachloride

     4. Chloroform

     5. *Water or ethyl alcohol acidified by tartaric acid

190. Extraction in the form of bases is one of the methods of alkaloids elimination. In this case raw materials are processed by:

     1. Hexane

     2. Formalin

     3. Carbon tetrachloride

     4. Chloroform

     5. *Water or ethyl alcohol acidified by tartaric acid

191. From the following list choose general alkaloid reagent:

     1. Frede

     2. Lughole

     3. Felling

     4. *Mayer

     5. Selivanov

192. From the following list choose general alkaloid reagent:

     1. Frede

     2. Lughole

     3. *Zonnenstein

     4. Felling

     5. Selivanov

193. From the following list choose general alkaloid reagent:

     1. Frede

     2. *Berthran

     3. Lughole

     4. Felling

     5. Selivanov

194. From the following list choose general alkaloid reagent:

     1. *Sheibler

     2. Lughole

     3. Frede

     4. Felling

     5. Selivanov

195. From the following list choose general alkaloid reagent:

     1. Frede

     2. Lughole

     3. *Dragendorff

     4. Felling

     5. Selivanov

196. From the following list choose general alkaloid reagent:

     1. Frede

     2. Lughole

     3. Selivanov

     4. Felling

     5. *Wagner-Bushard

197. From the following list choose specific alkaloid reagent:

     1. Felling

     2. *Erdman

     3. Lughole

     4. Selivanov

     5. Mayer

198. From the following list choose specific alkaloid reagent:

     1. Felling

     2. Selivanov

     3. Lughole

     4. *Frede

     5. Mayer

199. From the following list choose specific alkaloid reagent:

     1. *Marky

     2. Felling

     3. Lughole

     4. Selivanov

     5. Mayer

200. From the following list choose specific alkaloid reagent:

     1. Felling

     2. Mayer

     3. Lughole

     4. Selivanov

     5. *Mandelin

201. From the following list choose specific alkaloid reagent:

     1. Felling

     2. Lughole

     3. *Sodium nitroprusside

     4. Selivanov

     5. Mayer

202. Which of the following alkaloids does belong to pyridine and piperidine group?

     1. Quinine

     2. *Nicotine

     3. Morphine

     4. Codeine

     5. Atropine

203. Which of the following alkaloids does belong to pyridine and piperidine group?

     1. Isoquinoline

     2. Scopolamine

     3. Morphine

     4. Codeine

     5. *Anabasine

204. Which of the following alkaloids does belong to pyridine and piperidine group?

     1. Quinoline

     2. Codeine

     3. Papaverine

     4. *Lobeline

     5. Atropine

205. Which of the following alkaloids does belong to quinoline group?

     1. *Quinine

     2. Nicotine

     3. Morphine

     4. Codeine

     5. Atropine

206. Which of the following alkaloids does belong to isoquinoline and phenenthrene isoquinoline group?

     1. Nicotine

     2. Scopolamine

     3. Quinine

     4. *Papaverine

     5. Anabasine

207. Which of the following alkaloids does belong to isoquinoline and phenenthrene isoquinoline group?

     1. Nicotine

     2. *Morphine

     3. Quinine

     4. Lobeline

     5. Anabasine

208. Which of the following alkaloids does belong to isoquinoline and phenenthrene isoquinoline group?

     1. Atropine

     2. Papavarine

     3. *Codeine

     4. Quinine

     5. Anabasine

209. Which of the following alkaloids does belong to tropane group?

     1. *Atropine

     2. Nicotine

     3. Papaverine

     4. Quinine

     5. Morphine

210. Which of the following alkaloids does belong to tropane group?

     1. Nicotine

     2. *Scopolamine

     3. Codeine

     4. Quinine

     5. Morphine

211. Which of the following alkaloids does belong to tropane group?

     1. Papaverine

     2. Lobeline

     3. *Cocaine

     4. Quinine

     5. Morphine

212. Which of the following alkaloids does belong to indole group?

     1. Quinine

     2. *Reserpine

     3. Nicotine

     4. Morphine

     5. Cocaine

213. Which of the following alkaloids does belong to indole group?

     1. Codeine

     2. Cocaine

     3. Nicotine

     4. Morphine

     5. *Strychnine

214. To which group of alkaloids does theophylline belong?

     1. Indole

     2. Tropane

     3. *Purine

     4. Quinoline

     5. Pyridine and piperidine

215. To which group of alkaloids does theobromine belong?

     1. Indole

     2. Phenanthrene isoquinoline

     3. Quinoline

     4. *Purine

     5. Pyridine and piperidine

216. To which group of alkaloids does caffeine belong?

     1. Pyridine and piperidine

     2. Indole

     3. Isoquinoline

     4. Quinoline

     5. *Purine

217. To which group of alkaloids does nicotine belong?

     1. *Pyridine and piperidine

     2. Tropane

     3. Purine

     4. Quinoline

     5. Indole

218. To which group of alkaloids does anabasine belong?

     1. Phenanthrene

     2. Tropane

     3. Purine

     4. *Pyridine and piperidine

     5. Quinoline

219. To which group of alkaloids does lobeline belong?

     1. Indole

     2. *Pyridine and piperidine

     3. Piperidine

     4. Isoquinoline

     5. Pyridine

220. To which group of alkaloids does quinine belong?

     1. Isoquinoline

     2. Tropane

     3. Purine

     4. *Quinoline

     5. Pyridine and piperidine

221. To which group of alkaloids does papaverine belong?

     1. *Isoquinoline and phenanthrene isoquinoline

     2. Quinoline

     3. Tropane

     4. Indole

     5. Purine

222. To which group of alkaloids does morphine belong?

     1. Isoquinoline

     2. Quinoline

     3. *Isoquinoline and phenanthrene isoquinoline

     4. Indole

     5. Phenanthrene

223. To which group of alkaloids does codeine belong?

     1. Purine

     2. Pyridine and piperidine

     3. Indole

     4. Tropane

     5. *Isoquinoline and phenanthrene isoquinoline

224. To which group of alkaloids does atropine belong?

     1. Isoquinoline and phenanthrene isoquinoline

     2. Quinoline

     3. *Tropane

     4. Indole

     5. Purine

225. To which group of alkaloids does scopolamine belong?

     1. Phenanthrene isoquinoline

     2. Quinoline

     3. Isoquinoline

     4. *Tropane

     5. Indole

226. To which group of alkaloids does cocaine belong?

     1. Purine

     2. *Tropane

     3. Isoquinoline

     4. Indole

     5. Quinoline

227. To which group of alkaloids does reserpine belong?

     1. Isoquinoline and phenanthrene isoquinoline

     2. Quinoline

     3. Tropane

     4. *Indole

     5. Purine

228. To which group of alkaloids does strychnine belong?

     1. Tropane

     2. Quinoline

     3. *Indole;

     4. Isoquinoline

     5. Putine

229. Nicotine – alkaloid of pyridine and piperidine group in the little amount nicotine has:

     1. Spasmolytic action

     2. *Arousing effect on the autonomic system

     3. Antituberculosis action

     4. Antipyretic action

     5. Analgesic action

230. Nicotine, being a poisonous substance is used as:

     1. Flavor

     2. Stain

     3. Bleach

     4. Solvent

     5. *Insecticide

231. Anabasine – alkaloid of pyridine and piperidine group. Anabasine is used in the medicine as:

     1. *Mean against smoking

     2. Antituberculosis mean

     3. Expectorant mean

     4. Spasmolytic mean

     5. Sedative mean

232. Quinine – alkaloid of quinoline group. Quinine is used in the medicine as:

     1. *Antimalarial remedy

     2. Antituberculosis mean

     3. Expectorant mean

     4. Spasmolytic mean

     5. Sedative mean

233. Papaverine – alkaloid of quinoline and phenanthrene isoquinoline group. Papaverine is used in the medicine:

     1. Antimalarial remedy

     2. Antituberculosis mean

     3. Expectorant mean

     4. *Spasmolytic mean

     5. Sedative mean

234. What is the name of the following terpene?

1. α-pinene

2. squalene

3. limonene

4. *ocimene

5. myrcene

1. What is the name of the following terpene compound?

1. camfora

2. squalene

3. *limonene

4. ocimene

5. myrcene

1. Choose the product of β-lactose interaction with excess of acetic anhydride

1. 

2. 

3. 

4. 

5. *

1. What is the name of the following terpenoid?

1. menthol

2. *α-terpineol

3. farnesol

4. nerol

5. geraniol

1. Which group of compounds does menthol belong?

1. *diene aldehyde

2. diene alcohol

3. alicyclic aldehyde

4. bicyclic alcohol

5. monocyclic aldehyde

1. Which group of compounds does menthol belong?

1. bicyclic ketone

2. aliphatic alcohol

3. cycloalkane

4. *monocyclic alcohol

5. bicyclic alcohol

1. Which group of compounds does squalene belong?

1. monocyclic alkane

2. monocyclic alcohol

3. bicyclic alkane

4. *polyene

5. bicylic aldehyde

1. Which group of compounds does farnesol belong?

1. saturated alcohol

2. bicyclic ketone

3. *polyene alcohol

4. monocyclic alcohol

5. bicyclic alcohol

1. Choose the product of the following reaction?

1. camphene

2. terpin hydrate

3. terpin

4. α-pinene

5. *borneol

1. What is the name of the following terpene?

1. α-pinene

2. squalene

3. limonene

4. ocimene

5. *myrcene

1. What is the product of primary oxidation of camphor with nitric acid?

1. 

2. 

3. 

4. *

5. 

1. What is the product of nerol cyclization in acidic media?

1. 

2. 

3. *

4. 

5. 

553. Choose the number of chiral atom in the molecule of ¥á-terpineol.

1. 5

2. *4

3. 3

4. 2

5. 1

1. Choose the number of chiral atom in the molecule of limonene.

1. 5

2. *4

3. 3

4. 2

5. 1

1. Which group of compounds does geraniol belong?

1. bicyclic diene

2. aliphatic alcohol

3. diene alcohol

4. *diene alcohol

5. diene aldehyde

1. Which group of compounds does myrcene belong?

1. cycloalkane

2. bicyclic aldehyde

3. monocyclic aldehyde

4. *aliphatic polyene

5. aliphatic alcohol

1. Which of the following reagents can be used to distinguish phenylalanine from tyrosine?

1. 

2. 

3. 

4. *

5. 

1. Choose the correct definition of nucleotide.

   1. *nucleotide is the phosphoric acid ester of nucleoside

   2. nucleotide is N-glycoside, which consist of nucleobase and D-ribose

   3. nucleotide is the phosphoric acid ester of pyrimidine nucleobase

   4. nucleotide is the phosphoric acid ester of purine nucleobase

   5. nucleotide is the compound which consist of carbohydrate and heterocyclic nucleobase

2. What is the product of α-amino acids reaction with nitrous acid ?

   1. 

   2. 

   3. *

   4. 

   5. 

3. Choose the systematic name of α-cellobiose.

1. 

2. 

3. 

4. *

5. 

1. Choose the name of the following disaccharide.

1. *

2. 

3. 

4. 

5. 

1. How many chiral carbon atomes does β-D-fructofuranose have?

1. three

2. three

3. five

4. *four

5. one

1. Choose the product of D-glucose reduction.

   1. 

   2. 

   3. *

   4. 

   5. 

2. How many asymmetric carbon atoms does β-D-glucopyranose have?

1. six

2. *four

3. five

4. one

5. three

1. Among the peptides listed below choose the one with peptide sequence: alanine, glutamine and glycine (Ala-Glu-Gly).

   1. 

   2. 

   3. 

   4. *

   5. 

2. Among the peptides listed below choose the one with peptide sequence: glutamic acid, glycine and alanine (Glu-Gly-Ala).

   1. *

   2. 

   3. 

   4. 

   5. 

3. What is the name of the following terpenoid?

1. *α-pinene

2. squalene

3. limonene

4. ocimene

5. myrcene

1. What is the name of the following terpenoid?

1. menthol

2. α-terpineol

3. farnesol

4. *nerol

5. geraniol

1. What is the name of the following terpenoid?

1. *menthol

2. α-terpineol

3. farnesol

4. nerol

5. Geraniol

1. What is the name of the following terpenoid?

1. menthol

2. α-terpineol

3. farnesol

4. nerol

5. *geraniol

1. What is the name of the following terpenoid?

1. menthol

2. α-terpineol

3. *farnesol

4. nerol

5. geraniol

1. Which of the following reagents can be applied to obtain acyl halide from alanine?

1. 

2. 

3. 

4. 

5. *

1. Choose the name of the following disaccharide.

1. 

2. 

3. 

4. *

5. 

1. Choose the systematic name of β-maltose.

1. *

2. 

3. 

4. 

5. 

1. Choose the name of the following disaccharide.

1. β- maltose

2. *β-cellobiose

3. β- lactose

4. sucrose

5. α- maltose

1. Which of the following disaccharides gives galactose and glucose after hydrolysis?

   1. mannose

   2. cellobiose

   3. *lactose

   4. maltose

   5. sucrose

2. Choose the systematic name of beta-cellobiose.

1. 

2. 

3. 

4. *

5. 

1. Choose the systematic name of α-maltose.

1. 

2. 

3. *

4. 

5. 

1. The change of the specific rotation of sucrose solution caused by its hydrolysis is called:

   1. in all possible tautomeric forms

   2. *inversion

   3. mutorotation

   4. isomerization

   5. epimerization

2. The following monosaccharide belongs to:

1. deoxymonosaccharide

2. aldohexose

3. ketohexose

4. *ketopentose

5. aldopentose

1. What is the name of the following monosaccharide?

1. D–xylose

2. D–galactose

3. *D–glucose

4. D–mannose

5. D–fructose

1. What is the name of the following monosaccharide?

1. *L– mannose

2. L– galactose

3. D–galactose

4. L– glucose

5. D–glucose

1. Choose the correct definition for protein denaturation.

   1. *destruction of the protein form, with retention of primary structure of protein

   2. destruction of quaternary structure, with retention of primary secondary and tertiary structures of protein

   3. destruction of tertiary structure, with retention of primary and secondary structures of protein

   4. destruction of secondary structure, with retention of primary structure of protein

   5. destruction of primary structure of protein

2. What are the products of nucleic acids complete hydrolysis?

   1. *nucleobases, monosaccharides and phosphoric acid

   2. nucleobases, monosaccharides and water

   3. glycosides and phosphoric acid

   4. nucleosides and phosphoric acid

   5. nucleotides

3. What is the product of glycine reaction with ethanol?

1. 

2. *

3. 

4. 

5. 

1. Choose the cationic form of amino acids.

   1. 

   2. 

   3. *

   4. 

   5. 

2. Choose the product of borneol oxidation.

1. 

2. *

3. 

4. 

5. 

1. Choose the systematic name of β-lactose.

1. 

2. 

3. 

4. 

5. *

1. What are the products of glucose oxidation with Fehling’s reagent?

   1. *mixture of oxidation products + Cu2O

   2. glucaric acid + CuO

   3. gluconic acid + Cu

   4. glucuronic acid + Cu2O

   5. sorbitol + CO2

2. Which is the correct definition of epimeric monosaccharides?

   1. monoses, which have the different configuration of all chiral carbon atoms

   2. monoses, which have the different configuration of four chiral carbon atoms

   3. monoses, which have the different configuration of three chiral carbon atoms

   4. *monoses, which have the different configuration of one chiral carbon atom

   5. monoses, which have the different configuration of two chiral carbon atoms

3. What is the name of the following monosaccharide?

1. *D–mannose

2. L– galactose

3. D–galactose

4. L– glucose

5. D–glucose

1. What is the name of the following monosaccharide?

1. L–galactose

2. D–xylose

3. *D–ribose

4. L–arabinose

5. D–arabinose

1. Choose the correct systematic name of α -lactose.

1. 

2. 

3. 

4. 

5. *

1. Amylose (water-soluble fraction of starch) is planar polymer which consists of:

   1. 

   2. 

   3. *

   4. 

   5. 

2. Choose the correct complementary pair of nucleobases among the listed below.

   1. hypoxanthine - cytosine

   2. thymine - uracil

   3. uracil - hypoxanthine

   4. *adenine - thymine

   5. guanine - uracil

3. Which group of compounds does camphor belong?

1. cycloalkanol

2. aliphatic alcohol

3. bicyclic alkene

4. *bicyclic ketone

5. aliphatic ketone

1. Which group of compounds does limonene belong?