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Lead-in

  1. Fill in the gaps with the words in the list:

Data care objective detailed domain

  1. The main … of this laboratory is to study human genes.

  2. The object studied needs a more … analysis.

  3. USA is known for high standards of health … .

  4. The scientists have to study all the … before starting on the project.

  5. Studying genes with the help of computer programs is the … of bioinformatics.

  1. Answer the questions:

  1. What do you know about the Human Genome Project?

  2. How did you learn about it?

  3. What do you think is the main goal of the project?

  1. Read the text and say what the words in bold mean: Human Genome Project

The Human Genome Project (HGP) is an international scientific research project with a primary goal of determining the sequence of chemical base pairs which make up DNA, and of identifying and mapping the approximately 20,000–25,000 genes of the human genome from both a physical and functional standpoint.

The project began in October 1990 . A working draft of the genome was announced in 2000 and a complete one in 2003, with further, more detailed analysis still being published. The mapping of human genes is an important step in the development of medicines and other aspects of health care.

While the objective of the Human Genome Project is to understand the genetic makeup of the human species, the project has also focused on several other nonhuman organisms such as E. coli, the fruit fly, and the laboratory mouse. It remains one of the largest single investigative projects in modern science.

The Human Genome Project originally aimed to map the nucleotides contained in a human haploid reference genome (more than three billion). The "genome" of any given individual (except for identical twins and cloned organisms) is unique; mapping "the human genome" involves sequencing multiple variations of each gene. The project did not study the entire DNA found in human cells; some areas (about 8% of the total genome) remain un-sequenced.

The sequence of the human DNA is stored in databases available to anyone on the Internet. Computer programs have been developed to analyze the data, because the data itself is difficult to interpret without such programs.

The process of identifying the boundaries between genes and other features in a raw DNA sequence is called genome annotation and is the domain of bioinformatics.

All humans have unique gene sequences. Therefore the data published by the HGP does not represent the exact sequence of every individual's genome. It is the combined "reference genome" of a small number of anonymous donors. The HGP genome is a scaffold for future work in identifying differences among individuals.

Tasks:

  1. Answer the questions:

  1. What is the primary goal of the Human Genome Project?

  2. When did the project begin?

  3. Is the project finished now?

  4. Was only human DNA studied in the project?

  5. What does mapping of “the human genome” involve?

  6. Is the sequence of the human DNA an open information?

  7. What is genome annotation?

  8. What is “reference genome”?