Drugs affecting central nervous system General Anaesthetics

1. Proserinum in case of systemic administration increases the tone of skeletal muscles. Phthorotanum (halothane) causes relaxation of skeletal muscles and decreases the effects of proserinum. Call the character of interaction with proserinum and phthorotanum.

*A. Indirect functional antagonism.

B. Direct functional antagonism.

C. Competitive antagonism.

D. Independent antagonism.

E. Noncompetitive antagonism.

2. An anaesthesiologist has used nitrous oxide as general anaesthetic during operation. This drug has significant solubility in lipids. Indicate the mechanism of penetration of this drug through biological membranes.

*A. Passive diffusion.

B. Active transport.

C. Simplified diffusion.

D. Filtration.

E. Pinocytosis.

3. To anaesthetize the manipulation related to burn surface treatment, a patient was intravenously injected a drug for short-acting narcosis. A minute later increased blood pressure, tachycardia, increased tone of skeletal muscles; reflexes remained. After awakening the patient had disorientation and visual hallucinations. What drug was injected to patient?

*A. Ketamine.

B. Sombrevin.

C. Diethyl ether.

D. Thiopental sodium.

E. Nitrous oxide.

4. Proserin increases skeletal muscle tone when given systematically. Halothane induces relaxation of skeletal muscles and reduces proserin effects. What is the nature of proserin and halothane interaction?

*A. Independent antagonism.

B. Noncompetitive antagonism.

C. Competitive antagonism.

D. Direct functional antagonism.

E. Indirect functional antagonism.

5. For inithial anaesthesia, anaesthesiologist administers thiopenthal sodium to patient. Owing to this, hypersalivation and laryngospasm are developed in patient. Which drug can prevent these complications?

*A. Atropine.

B. Adrenaline.

C. Proserinum.

D. Ephedrine.

E. Salbutamol.

6. For general anaesthesia, anaesthesiologist uses combination of inhaled anaesthetic and derivative of barbituric acid. Choose this combination.

*A. Thiopenthal sodium and halothane.

B. Promedolum and halothane.

C. Nitrous oxide and ketamine.

D. Halothane and fentanyl.

E. Droperidol and ether.

7. Acute hepatitis developed in patient after surgery with reuse of sorting general anaesthetic. Which anaesthetic drug is used?

*A. Halothane (phthorotanum).

B. Nitrous oxide.

C. Thiopenthal sodium.

D. Propanidid.

E. Ether.

8. Anaesthesiologist administers to a patient general anaesthetic with prolonged phase of the excitation. Which drug is administered?

*A. Ether.

B. Phthorotanum (halothane).

C. Nitrous oxide.

D. Propanidid.

E. Oxybutirate sodium.

9. Progressive drop of blood pressure is developed in patient under general anaesthesia. Doctor administers to him the injection of adrenaline. Owing to this, ventricular fibrillation is developed in patient. Call general anaesthetic which is used for narcosis in this case.

*A. Phthorotanum.

B. Nitrous oxide.

C. Oxytutirate sodium.

D. Thiopental sodium.

E. Ketamine.