Adrenoblocking Drugs

1. A doctor prescribed antihypertensive drug to patient, who suffers from hypertensive disease and obstructive bronchitis. After some time asthma attacks have arisen in patient and expressed bradycardia has developed. In ECG the signs of AV blockade were observed. Choose drug, for which these adverse effects are most common.

*A. Anaprilinum (propranolol).

B. Clophelinum (Clonidine).

C. Talinolol (Cordanum).

D. Verapamil.

E. Reserpine.

2. A doctor prescribed the antihypertensive drug to patient, who suffers from hypertensive disease and obstructive bronchitis. After some time asthma attacks have arisen in patient. What is the cause of this adverse effect?

*A. Blockade of bronchial ₂-adrenoceptors.

B. Blockade of bronchial ₁-adrenoceptors.

C. Stimulation of bronchial ₂-adrenoceptors.

D. Blockade of bronchial ₂-adrenoceptors.

E. Stimulation of bronchial ₁-adrenoceptors.

3. A patient stays on hospitalization concerning a bronchial asthma. Hypertonic disease is diagnosed as accompanying disease. Indicate drug, which is contraindicated for this patient.

*A. Anaprilinum (propranolol).

B. Papaverine hydrochloride.

C. Atropine sulfate.

D. Salbutamol.

E. Ephedrine hydrochloride.

4. A patient with pheochromocytoma suffers from increased blood pressure, which develops in hypertensive crisis. What drug group is useful in this case?

*A. -Adrenoblockers.

B. -Adrenoblockers.

C. Ganglion blockers.

D. Sympatholytics.

E. Blockers of Ca²⁺ channels.

5. Rapid and significant decrease o f blood pressure is the main way of interruption of hypertensive crisis. The injection of which group of antiadrenergic drugs is available for this purpose?

*A. -Adrenoblockers.

B. Non-selective -adrenoblockers.

C. Cardioselective -adrenoblockers.

D. Sympatholytics.

E. All answers are not correct.

6. Bronchospasm has developed in patient with angina pectoris after taking of antihypertensive drug. What drug was taken by the patient?

*A. Propranolol (anaprilinum).

B. Nitroglycerin.

C. Sustac.

D. Nifedipine.

E. Dipyridamole.

7. A doctor has prescribed propranolol to 36-year-old female with ischaemic heart disease. But having found out presence of accompanying disease, the doctor replaced propranolol by atenolol. What disease is the cause of this replacement?

*A. Bronchial asthma.

B. Arterial hypertension.

C. Ulcer disease of duodenum.

D. Myasthenia.

E. Cholecystitis.

8. A 60-year-old female suffers from toxic goiter and complains of a tachycardia. What drug should be prescribed for normalization of cardiac rhythm?

*A. Anaprilinum (propranolol).

B. Isadrinum (isoproterenol).

C. Salbutamol.

D. Adrenaline (Epinephrine).

E. Pentamine.

9. A patient with diabetes mellitus has taken the dose of long-acting insulin in the morning, but did not take food. After some time the patient has got the following signs: weakness, headache, dizziness, trembling, and convulsions. What drug should be introduced for interruption of hypoglycaemia?

*A. Adrenaline.

B. Triamcinolone.

C. Noradrenaline.

D. Prednisolone.

E. Hydrocortisone.

10. A patient with ischaemic heart disease did not inform to doctor, that he has attacks of bronchospasm. The doctor has prescribed to him the drug A. After that the attacks of angina pectoris are rare, but attacks of bronchospasm are more often. Call the drug, which was prescribed to the patient.

*A. Anaprilinum (propranolol).

B. Atenolol.

C. Verapamil.

D. Diltiazem.

E. Nitrosorbide.

11. Broncho-obstructive syndrome (deterioration of breathing, cough) has developed in patient during the treatment of сiliary arrhythmia. Indicate the antiarrhythmic drug which can cause such complication.

*A. Anaprilinum (propranolol).

B. Ajmalin.

C. Nifedipine.

D. Verapamil.

E. Novocainamidum (procainamide).

12. A doctor has prescribed anaprilinum to patient who suffers from hypertensive disease. In two weeks from the start of treatment the patient began to complain of feeling of asthma and deterioration of breathing. Explain the possible cause of this complication and doctor’s tactics in this case.

*A. Blockade of β₂adrenoceptors. Prescribe selective β₁-adreno-blocker.

B. Blockade of β₁-adrenoceptors. Prescribe selective β₂-adreno-blocker.

C. Myotropic bronchospastic action. Prescribe euphyllinum (aminophylline).

D. Excitation of M-cholinoceptors. Prescribe atropine.

E. Allergic reaction. To cancel anaprilinum and prescribe H₁-histaminoblockers.

13. A 50-year-old female suffers from hypertensibe disease and ulcer disease of stomach with increased production of hydrochloric acid. Indicate drug, which is contraindicated to this patient for treatment of hypertensive disease.

*A. Reserpine.

B. Dibazole.

C. Spironolactone.

D. Furosemide.

E. Nifedipine (phenihydinum).

14. A 50-year-old patient suffers from ischaemic heart disease, сiliary arrhythmia, and cardiosclerosis. Choose the drug, which is necessary to prescribe to this patient.

*A. Metoprolol

B. Acetylsalicylic acid

C. Digoxin

D. Strophanthine

E. Potassium chloride

15. A patient who suffers from hypertensive disease of the I stage, took drug A. in tablets. In several weeks he began feeling pain in stomach, nausea, apathy, sleepiness. What drug is the cause of these adverse effects?

*A. Reserpine.

B. Chlorothiazide (dichlothiazidum).

C. Octadinum.

D. Phenihydinumю

E. Captopril.

16. It is necessary to prescribe antiarrhythmic drug to patient who suffers from сiliary arrhythmia and bronchial asthma. Indicate antiarrhythmic drug which is contraindicated to this patient.

*A. Anaprilinum (propranolol).

B. Ajmalin.

C. Verapamil.

D. Nifedipine.

E. Novocainamidum (procainamide).

17. Anaprilinum therapy caused positive effect in the dynamic of the disease of 44-year-old woman suffering from stenocardia. What is the main mechanism of the effect of this drug?

*A. Blockade of -adrenoceptors and decrease of myocardial requirements to the oxygen.

B. Increased oxygen supply to the myocardium.

C. Decreased power inputs of myocardium due to reduced loading.

D. Decreased need in increasing of oxygen supply to the myocardium.

E. Decrease of oxidative exchange in myocardium due to enzyme blockade of Krebs cycle.

18. Propranolol has been prescribed to a 36-year-old female patient suffering from ischaemic heart disease. But the doctor decided to replace this drug by atenolol due to concomitant disease. What disease was found by the doctor?

*A. Bronchial asthma.

B. Arterial hypertension.

C. Duodenal ulcer.

D. Myasthenia.

E. Cholecystitis.

19. A 60-year-old woman, suffering from toxic goiter, complains of constant palpitation. What drug should be prescribed for normalization of heart rate?

*A. Propranololum.

B. Isadrinum.

C. Salbutamolum.

D. Adrenalini hydrochloridum.

E. Pentaminum.

20. For the treatment of angina a selective ₁-adrenergic blocker, which has no internal sympathomimetic activity, was prescribed. It is known that the drug is lipophilic, has average duration of action and is produced in tablets and ampoules. What is this drug?

*A. Metoprololum.

B. Talinololum.

C. Benzohexonium.

D. Drotaverini hydrochloridum.

E. Propranololum.

21. Therapy with propranolol has positively affected the course of the disease of a 44-year-old woman with angina pectoris. What is the mechanism of antianginal action of this drug?

*A. Inhibition of ₁-adrenoceptors and decrease of the need of the myocardium for oxygen.

B. Decrease of the oxidative exchange in the myocardium due to the inhibition of the enzymes of Krebs cycle.

C. Decrease of myocardium energy consumption due to the decrease of load.

D. Increase of oxygen coming into the myocardium.

E. Decrease of the need for oxygen and increase of the coming of oxygen into the myocardium.

22. A patient suffering from ischaemic heart disease did not inform the doctor about the attacks of bronchospasm he sometimes had, the doctor prescribed a drug, the intake of which made the attacks of angina pectoris less frequent, but the attacks of bronchospasm became more frequent. What drug has been prescribed?

*A. Propranololum.

B. Verapamilum.

C. Nitrosorbitum.

D. Nitroglycerinum.

E. Diltiazemum.

23. For the treatment of ischaemic heart disease a patient has been given -adrenoreceptor antagonist. After a while he had a cough and bronchospasm. Which of the drugs has such evident side action?

*A. Propranololum.

B. Talinololum.

C. Atenololum.

D. Nifedipinum.

E. Metoprololum.

24. Bronchoconstriction has developed in hypertensive patient after reception of drug. What drug causes bronchoconstriction?

*A. Propranolol.

B. Nitroglycerin.

C. Corglycon.

D. Amiodarone.

E. Isosorbide mononitrate.

25. Antihypertensive agent has decreased the blood pressure during first several days of treatment owing to diminish of minute heart volume. In four weeks of using, minute heart volume restored to initial level but blood pressure had remained low. Indicate drug which is used in this case.

*A. Anaprilinum.

B. Prazosin.

C. Methyldopa.

D. Octadine.

E. Losartan.

26. Drag A. is prescribed to patient with ischaemic heart disease for prevention of angina attacks. Indicate this drug.

*A. Metoprolol.

B. Atropine sulfate.

C. Morphine.

D. Oxytocin.

E. Furosemide.

27. A patient with hypertensive disease is delivered to cardiologic department. The doctor prescribed him the hypotensive drug which blocks both ₁- and ₂-adrenoceptors. Indicate this drug.

*A. Anaprilinum.

B. Proserinum.

C. Celecoxib.

D. Prednisolon.

E. Indometacine.

28. A patient with coronary artery disease was admitted to the cardiological department. For stenocardia prevention a drug from the group of β-adrenoceptor blockers was administered. What drug is it?

*A. Metoprolol.

B. Morphine hydrochloride.

C. Oxytocin.

D. Furosemide.

E. Atropine sulfate.