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Step-1 Pharmacology (for students).doc
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Antitumoral Drugs. Radioprotectors

1. Methotrexate (structural analogue of the folic acid which is competitive inhibitor of the duhydrofolatreductase) is prescribed for treatment of the malignant tumour. On which level does methotrexate hinder synthesis of the nucleic acid?

*A. Mononucleotide synthesis

B. Reparation

C. Replication

D. Processing

E. Transcription

2. The preventive radio-protector was given to a worker of a nuclear power station. What mechanism from the follow mentioned is considered to the main mechanism of radioprotection?

*A. Inhibition of free radicals formation

B. Increasing of respiration

C. Activation of oxidation reactions

D. Prevention of tissue’s hypoxia

E. Increasing of tissue blood supply

3. An oncological patient was administered methotre-xate. With the lapse of time the target cells of the tumor lost sensitivity to this drug. We can observe changes in the gene expression of the following enzyme:

*A. Dihydrofolate reduc-tase

B. Desaminase

C. Folate oxidase

D. Folate decarboxylase

E. Thiminase

Contents

General Pharmacology..........................................

.......3

Drugs Influencing Peripheral Nervous System.......................

.....15

Drugs Affecting the Afferent Innervation....................................

.....15

Cholinomimetic Drugs and Cholinesterase Inhibitors.................

.....20

M-Cholinoblocking Drugs...........................................................

.....29

N-Cholinoblocking Drugs............................................................

.....36

Adrenomimetic Drugs and Sympathomimetics...........................

.....42

Adrenoblocking Drugs.................................................................

.....54

Drugs Affecting Central Nervous System................................

.....61

General Anaesthetics....................................................................

.....61

Hypnotic Drugs. Ethyl Alcohol....................................................

.....63

Antiepileptic and Antiparkinsonic Drugs....................................

.....66

Opioid Analgesics........................................................................

.....70

Non-Steroid Antiinflammatory Drugs (Non-Opioid Analgesics)

.....78

Antipsychotics, Antidepressants, and Litium Salts......................

.....81

Tranquilizers and Sedative Drugs................................................

.....85

Psychostimulants, Nootropics, and Analeptics............................

.....87

Drugs which Influence Functions of Internal Organs............

.....90

Drugs Affecting Respiratory System...........................................

.....90

Cardiotonic Drugs........................................................................

.....94

Drugs Used for Treatment of Ischemic Heart Disease.................

.....99

Antiarrhythmic Drugs..................................................................

...106

Antihypertensive and Hypertensive Drugs..................................

...112

Drugs Influencing Secretion of Gastrointestinal Tract................

...117

Drugs Influencing Motility of Gastrointestinal Tract..................

...122

Diuretic Drugs. Drugs Influencing Uterus. Drugs for

Treatment of Goat........................................................................

...125

Drugs Influencing Erythro- and Leucopoesis..............................

...131

Antiagregants, Anticoagulants, and Drugs Affecting

Fibrinolysis..................................................................................

...134

Antimicrobial, Antifungal, Antiviral, and Antiprotosoal Drugs...........................................................................................

...136

Antiseptics and Disinfectants.......................................................

...136

Antibiotics....................................................................................

...138

Sulfonamides. Synthetic Antimicrobial Drugs............................

...141

Antitubercular Drugs. Antisyphilitic Drugs.................................

...143

Antifungal and Antiviral Drugs....................................................

...145

Antiprotosoal Drugs.....................................................................

...146

Antihelmintic Drugs.....................................................................

...149

Drugs Influencing Metabolism..................................................

...149

Endocrine Drugs..........................................................................

...149

Vitamins.......................................................................................

...166

Antiallergic and Immunotropic Drugs.........................................

...169

Antitumoral Drugs. Radioprotectors............................................

...176

180

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