Sulfonamides. Synthetic Antimicrobial Drugs

1. Gonorrhea was revealed in the patient on bacterioscopy of the smear from urethra. Taking into account that medicines for gonorrhea are fluorquinolones, patient should be prescribed:

*A. Ciprofloxacin

B. Urosulfan

C. Furasolidone

D. Cefazoline

E. Fluorouracil

2. Patient with pneumonia has intolerance to antibiotics. Which of the combined sulfanilamide drug should be prescribed to this patient?

*A. Biseptol

B. Streptocid

C. Aethazol

D. Sulfadimethoxine

E. Natrium sulfacyl

3. The relative granulocy-topenia is observed in patient after course of treatment with sulfonamides. It is known that patient has tendency to allergies. Which immunologic process is cause of granulocy-topenia?

*A. The lyses of leucocytes of which are acquired of antigenic properties

B. Decrease of immunologic tolerance

C. Formation of immunologic complexes in blood

D. Increased activity of killer lymphocytes

E. Increased activity of macrophages

4. Combined sulfonamide drug with bactericidal effect was prescribed to patient with pneumonia. Which drug was prescribed?

*A. Bactrim

B. Aethazolum (sulfa-ethidole)

C. Norsulfazolum (sulfa-thiazole)

D. Sulfalene

E. Phthalazolum (phthalyl-sulfathiazole)

5. Doctor prescribes Biseptol to patient with tonsillitis. What is priority of Biseptol in comparison with other sulfon-amides?

*A. Trimethoprim blocks the next stage of folic acid metabolism

B. Trimethoprim increases the imitation of PABA by sulfonamides

C. Biseptol better penetrates into the microorganisms

D. Trimethoprim decreases the biotransformation of sulfonamide

E. Biseptol has less degree of binding with plasma proteins

6. Doctor prescribes sulfon-amide to patient with pneumonia. Whot is mechanism of action of sulfonamides?

*A. Competitive antagonism with para-aminobenzoic acid (PABA)

B. Blockage of SH-groups of bacterial enzymes

C. Regulation of vessels tone

D. Influence upon bacterial cell wall

E. Increase of permeability of bacterial cell membrane

7. Patient with bacterial dysentery receives phthalazolum. Why this drug is used only for treatment of intestinal infec-tions?

*A. Drug acts only into the intestine because don’t absorbed into the blood

B. Drug has high degree of reabsorption in the kidneys

C. Drug undergoes entero-hepatic circulation

D. Drug is easily absorbed in the blood

E. Drug easily eliminated from the body

8. Patient received sulfalene for treatment of chronic infection. The hemolysis of erythrocytes develops in patient in several days after initiation of treatment. Deficiency of which enzyme is cause of this complication?

*A. Glucose-6-phosphate dehydrogenase

B. Cholinesterase

C. Acetaldehyde dehydro-genase

D. MAO

E. N-acetyltransferase

9. 7-years-old child receives phthalazolum for treatment of enterocilitis. What is mechanism of drug action?

*A. Inhibition of dihydro-pteroate synthase

B. Inhibition of DNA-po-lymerase

C. Inhibition of RNA-po-lymerase

D. Inhibition of DNA-tran-scriptase

E. Blockage of peptidyl transferase

10. Doctor prescribed the sulfonamide for treatment of patient with infection of urinary tract. Which drug was prescribed by doctor?

*A. Urosulfanum

B. Phthalazolum

C. Sulginum

D. Sulfacylum-sodium

E. Sulfadimethoxine