Antibiotics

1. A 19-year-old patient has primary syphilis. He gets a complex therapy. Benzylpenicilline sodium is a part of this therapy. What is the mechanism of the action of this drug?

*A. Blockade of microbe membrane peptidoglycane synthesis

B. Blockade of cytoplasm proteins synthesis

C. Blockade of thiol enzyme groups

D. Blockade of RNA synthesis

E. Blockade of DNA synthesis

2. A 27-year-old woman has dropped penicillin containing eye drops. In few minutes there appeared feeling of itching, burning of skin, lips and eyelids edema, whistling cough, decreasing of blood pressure. What antibodies take part in the development of this allergic reaction?

*A. IgE and IgG

B. IgG and IgD

C. IgM and IgD

D. IgM and IgG

E. IgA and IgM

3. Patient was admitted to the infection unit with diagnosis of bacterial dysentery. On laboratory studies it was revealed that causative element is sensitive to the many antimicrobial medicines, but patient has anemia. What drug is contraindicated to the patient?

*A. Levomycetin

B. Enteroseptol

C. Ampicillin

D. Phthalazol

E. Furazolidone

4. A patient was admitted to the infection unit with diagnosis of bacterial dysentery. On laboratory studies it was revealed that causative element is sensitive to many antimicrobial medicines, but patient had anemia. What medicine was contraindicated to the patient?

*A. Levomycetin

B. Enteroseptol

C. Furazolidone

D. Ampicillin

E. Phthalazol

5. The patient with pneumonia was treated with antibiotics for a long period. After treatment patient complains of frequent and watery stool, abdominal pain. What is the reason of intestine function disorder?

*A. Intestinal disbacteriosis development

B. Antibiotic toxic influence on the GIT

C. Hereditary enzyme defect

D. Autoimmune reaction development

E. Bacteria toxins influence

6. 60-year-old patient was admitted to the surgical department because of infection caused by blue pus bacillus (pseudomonas aeruginosa) which is sensitive to penicillin antibiotics. Indicate which of the given penicillins has marked activity to the Pseudomonas aeruginoca?

*A. Carbenicillin disodium

B. Benzylpenicillin

C. Phenoxymethylpenicillin

D. Oxacillin

E. Methacillin

7. A 50-year-old patient with typhoid fever was treated with levomycetin. The next day his condition became worse, temperature raised to 39.6⁰C. What caused worsening?

*A. The effect of endotoxin agent

B. Secondary infection addition

C. Irresponsiveness of an agent to the levomycetin

D. Reinfection

E. Allergic reaction

8. The penicillin-induced epilepsy has developed in 28-year-old patient in result of antibiotic-therapy. What drug can cause this complication?

*A. Benzylpenicillin sodium

B. Doxicicline

C. Rifampicin

D. Amoxicillin

E. Isoniazid

9. The serious generalized septic infection menacing to life has developed in patient. What of the listed groups of chemotherapeutic agents should be used in this case?

*A. Cephalosporines

B. Еetracyclines

C. Sulfonamides

D. Laevomycetin

E. Macrolides

10. Treatment course of bacterial pneumonia included benzylpenicillin sodium salt. What is the mechanism of its antimicrobial action?

*A. Inhibition of cell wall synthesis of the microorganism

B. Antagonism with the paraaminobenzoic acid

C. Inhibition of the intracellular protein synthesis

D. Inhibition of the SH-groups of enzymes of the microorganisms

E. Inhibition of the cholinesterase activity

11. A patient suffering from stomach ulcer has been treated with an antacid drug Almagel. For acute bronchitis treatment he was prescribed the antibiotic methacicline. However, within next 5 days the fever didn’t fall, cough and sputum nature remained unchanged. A physician came to the conclusion that the drugs were incompatible. What type of drug incompatibility is the case?

*A. Pharmacokinetic, absorption stage

B. Pharmaceutic

C. Pharmacokinetic, biotransformation stage

D. Pharmacodynamic

E. Direct antagonism

12. As a result of durative antibiotic therapy a 37-year-old patient developed intestinal dysbacteriosis. What type of drugs should be used in order to normalize intestinal microflora?

*A. Eubiotics

B. Sulfanilamides

C. Bacteriophages

D. Autovaccines

E. Vitamins

13. A doctor prescribed a cephalosporin antibiotic to the patient after appendectomy for infection prevention. Antimicrobial activity of this group of antibiotics is based upon the disturbance of the following process:

*A. Microbial wall formation

B. Ribosome protein synthesis

C. Energy metabolism

D. Nucleic acid synthesis

E. Choline esterase block