Drugs Influencing Erythro- and Leucopoesis

1. Methotrexate (structural analogue of the folic acid which is competitive inhibitor of the duhydrofolatreductase) is prescribed for treatment of the malignant tumour. On which level does methotrexate hinder synthesis of the nucleic acid?

*A. Mononucleotide synthesis

B. Reparation

C. Replication

D. Processing

E. Transcription

2. A nucleophilic attack on deoxyribonucleic acid that causes the disruption of base pairing occurs as a result of the administration of:

*A. Cyclophosphamide

B. Methotrexate

C. Prednisolone

D. Filgrastim

E. Mercaptopurine

3. Which of the following is a chemotherapeutic drug that possesses a mechanism of action involving alkylation?

*A. Myelosan

B. Fercoven

C. Methotrexate

D. Pentoxylum

E. Vincristine

4. Binding to the enzyme dihydrofolate reductase is the mechanism of action for:

*A. Methotrexate

B. Cyclophosphamide

C. Molgramostim

D. Sodium phosphate with radioactive ³²P

E. Vincristine

5. Which of the following is considered to be the effective mechanism of action of the vinca alkaloids?

*A. Inhibition of the function of microtubules

B. Damage and prevention of repair of DNA

C. Inhibition of DNA synthesis

D. Inhibition of protein synthesis

E. Inhibition of purine synthesis

6. A 34-year-old male with Hodgkin’s disease is treated with combined chemotherapy with used of vinblastine. What is the mechanism of action of this drug?

*A. Prevention of assembly of tubulin dimers onto microtubules

B. Inhibition of dihydrofolate reductase

C. Inhibition of enzymes involved in purine metabolism

D. Inhibiotion of topoisimerase

E. Scission of DNA strands

7. A 45-year-old male on combination therapy for remission-maintenance acute lymphocytic leukemia develops suprapubic pain, dysuria, and hematuria. Evidence of hemorrhage and inflammation is apparent on cystoscopy of the urinary bladder. Which of the following agents most likely caused these findings?

*A. Cyclophosphamide

B. Methotrexate

C. Mercaptopurine

D. Doxorubicin

E. Vincristine

8. Which vitamin can mask the symptoms of pernicious anemia by alleviating the anemia but not preventing the neurological damage?

*A. Folic acid

B. Niacin

C. Vitamin B₁₂

D. Vitamin C

E. Vitamin D

9. Neurotoxicity is rarely dose limiting in cancer chemotherapy.The only antineoplastic agent that has a dose-limiting neurotoxicity is:

*A. Vincristine

B. Cisplatin

C. Bleomycin

D. Doxorubicin

E. Methotrexate

10. Which class of drugs bind avidly to tubulin and cause arrest of cells in metaphase?

*A. Vinca alkaloids

B. Nitrogen mustards

C. Alkylating agents

D. Antiestrogens

E. Antimetabolites

11. Methotrexate (structural analogue of the folic acid which is competitive inhibitor of the duhydrofolatreductase) is prescribed for treatment of the malignant tumour. On which level does methotrexate hinder synthesis of the nucleic acid?

*A. Mononucleotide synthesis

B. Reparation

C. Replication

D. Processing

E. Transcription

12. After the examination of a 40-year-old man the diagnosis of hypochromic anemia was made. What drug should be prescribed for this patient?

*A. Fercovenum

B. Cyanocobalaminum

C. Pentoxylum

D. Heparinum

E. Vikasolum

13. A pregnant woman’s blood analysis revealed megaloblasts and a high color index. The diagnosis is megaloblastic anemia. What drug should be prescribed to the patient?

*A. Cyanocobalaminum

B. Pyridoxini hydrochloridum

C. Acidum nicitinicum

D. Acidum ascorbinicum

E. Coamidum