Drugs Influencing Secretion of Gastrointestinal Tract

1. A 37-year-old man was admitted to the surgical department with symptoms of acute pancreatitis: vomiting, diarrhea, bradycardia, hypotension, weakness, dehydration of the organism. What medicine should be used first of all?

*A. Contrical

B. Platyphylline

C. Etaperazine

D. Ephedrine

E. No-spa

2. Cimetidine slows the metabolism of many drugs because it inhibits the activity of:

*A. Cytochrome P-450

B. Monoamine oxidase (MAO)

C. Tyrosine kinase

D. H⁺,K⁺-ATPase

E. Phase II glucuronidation reactions

3. The absorption of phosphate is reduces when large and prolonged doses of which of the following antacids are given?

*A. Calcium carbonate

B. Magnesium hydroxide

C. Magnesium trisilicate

D. Sodium bicarbonate

E. Sucralfate

4. Omeprazole, an agent for the promotion of healing of peptic ulcers, has a mechanism of action that is based on:

*A. H⁺,K⁺-ATpase

B. Gastric secretion

C. Pepsin secretion

D. Prostaglandins

E. Anticholinergic action

5. The approved indication for misoprostol:

*A. Prevention of gastric ulceration in patients using large doses of aspirin-like drugs

B. Regional ileitis

C. Ulcerative colitis

D. Reflux esophagitis

E. Pathologic hypersecretory conditions such as Zollinger-Ellison syndrome

6. Bismuth salts are thought to be effective in peptic ulcer disease because they have bactericidal properties against:

*A. Helicobacter pylori

B. Bacteroides fragilis

C. Clostridium difficile

D. Escherichia coli

E. Staphylococcus aureus

7. Misoprostol has a cytoprotective action on the gastrointestinal mucosa because it:

*A. Enhances secretion of mucus and bicarbonate ion

B. Neutralizes acid secretion

C. Antagonizes nonsteroidal anti-inflammatory drugs

D. relieves ulcer symptoms

E. Coats the mucosa

8. The primary pharmacological action of omeprazole is the reduction of:

*A. Secretion of gastric acid

B. Gastric motility

C. Secretion of pepsin

D. Volume of gastric juice

E. Secretion of intrinsic factor

9. Which of the following is not associated with sucralfate?

*A. It has moderate acid-neutralizing properties

B. It maintains gel-like qualities even at acid pH

C. It binds to ulcer craters more than to normal mucosa

D. It contains polyaluminum hydroxide

E. It reacts little with mucin

10. Preferred drug therapy for Zollinger-Ellison syndrome:

*A. Omeprazole

B. Sucralfate

C. Misoprostol

D. Ranitidine

E. Metronidazole

11. A 36-year-old woman with severe erosive esophagitis is prescribed pantoprazole. One of the most common adverse side effects of such therapy is which of the following?

*A. Headache

B. Constipation

C. Vomiting

D. Heartburn

E. Paresthesias

12. While taking a NSAID for arthritis, a 65-year-old man developed a gastric ulcer. He was prescribed ranitidine for 8 weeks. This drug binds a receptor located where?

*A. Cell membrane

B. Nucleolus

C. Cytoplasm

D. Nucleus

E. Cell wall

13. Gastric acid secretion is stimulated by the presence of:

*A. Gastrin and acetylcholine

B. Histamine and motilin

C. Norepinephrine and gastrin

D. Norepinephrine and histamine

E. Acetylcholine and pepsin

14. The physician must always be aware of possible drug interactions. Aluminum hydroxide antacids tend to interfere with the gastrointestinal absorption of:

*A. Tetracycline

B. Penicillin G

C. Erythromycin

D. Chloramphenicol

E. Cephalexin

15. One mechanism to reduce gastric acid secretion is by blocking the H⁺,Na⁺-TPase pump in the parietal cell. One drug that has this pharmacologic action is:

*A. Omeprazole

B. Pirenzepine

C. Misoprostol

D. Serotonin

E. Isoniazid

16. The concomitant administration of calcium and/or magnesium antacids to patients receiving one of the tetracycline drugs may have which of the following effects upon the action of the tetracycline:

*A. Decreases the action

B. Causes no significant change

C. Enhances the action

D. Increases toxicity

E. Suppresses hypersensitivity reactions

17. Famotidine is prescribed to a patient with gastric ulcer. The acidity of gastric juice has considerably decreased. What mechanism underlies the action of the drug?

*A. Blockade of H₂-histaminic receptors

B. Blockade of H₁-histaminic receptors

C. Blockade of M₁-cholinoceptors

D. Suppression of the activity of Na,K-ATPase

E. Blockade of N-cholinoceptors

18. A 40-year-old patient suffers from gastric ulcer at the stage of exacerbation accompanied by a substantial increase of the acidity of gastric juice, pain, and dyspeptic syndrome. Choose the drug for treatment of this patient:

*A. Famotidinum

B. Allocholum

C. Papaverini hydrochloridum

D. No-spa

E. Festal

19. A patient complains of stomachache, heartburn. Tests revealed the increase of gastric juice acidity. What drug should be prescribed to the patient for neutralization of the excessive acidity of gastric juice?

*A. Almagelum

B. Atropine

C. Papaverini hydrochloridum

D. Ranitidine

E. Benzohexonium

20. A patient with stomach ulcer has Helicobacter pylori detected. What drug, which influences Helicobacter pylori, is should be prescribed in this case?

*A. Metronidazole

B. Almagelum

C. Famotidinum

D. Atropine sulfate

E. Maalox

21. To patient with ulcer disease of stomach was prescribed drug, the mechanism of which action bases on the blockade of H2 hystamine receptors. Call this drug.

*A. Famotidine

B. Bisacodylum

C. Omeprazol

D. Atropine sulfate

E. Dithylinum

22. A patient suffering from chronic hyperacidic gastritis takes an antacid drug for heartburn elimination. After its ingestion the patient feels better but at the same time he has a sensation of stomach swelling. Which of the following drugs might be the cause of such side effect?

*A. Sodium hydrocarbonate

B. Pepsin

C. Magnesium oxide

D. Magnesium trisilicate

E. Aluminium hydrooxide