(Non-Opioid Analgesics)

1. After the usage of acetylsalicylic acid a patient developed epigastric pain because of exacerbation of his ulcer. What are the principles of this medication ulcerogenity?

*A. Antiprostaglandinic effect

B. Spasm of vessels

C. Immunodepressive effect

D. Cholagogic effect

E. Stimulation of pepsin secretion

2. Aspirin has antiinflammatory effect due to inhibition of the cyclooxygenase activity. Level of what biological active compounds will decrease?

*A. Prostaglandins

B. Catecholamines

C. Leucotrienes

D. Iodinethyronyns

E. Biogenic amines

3. Signs of gastropathy develop in the patient with rheumatoid arthritis who was treated with indometacin. What activity of the drug does cause this complication?

*A. Anticyclooxygenase

B. Antiserotonin

C. Local irritating

D. Antikinine

E. Antihistamine

4. A child with hyperthermia has been prescribed a drug, which is an active metabolite of phenacetine, has strong antipyretic action. It can be inactivated by conjugation with glutathione. In toxic doses it can damage liver cells. Antidotes in case of poisoning are acetylcysteine and methionine. What is this drug?

*A. Paracetamolum

B. Atropini sulfas

C. Phosphacolum

D. Coffeinum-natrii benzoas

E. Phenobarbitalum

5. A patient with a headache was prescribed a drug – a derivative of pyrazolone, which has analgesic and antipyretic action. It has negative influence on hemopoiesis in case of long application. It is forbidden as monotherapy in the countries of the Schengen Agreement. What is this drug?

*A. Analginum

B. Paracetamolum

C. Pyracetamum

D. Aminazinum

E. Aethimizolum

6. The patient with arthritis of knee joint also suffers from ulcer disease of stomach. What drug is preferable to pain relief in knee joint for this patient?

*A. Celecoxib

B. Analginum

C. Aspirin

D. Promedolum

E. Tramal

7. The 25-year-old patient used for relief of toothache the non-opioid analgesic from group of aniline derivatives. What is this drug?

*A. Paracetamol

B. Acetylsalicylic acid

C. Analginum

D. Butadionum

E. Ibuprofen

8. The prolonged using of nonsteroid anti-inflammatory drug in patient with arthritis and varicose phlebectasia has caused the thrombosis of skin veins. Indicate drug which can cause this complication.

*A. Celecoxib

B. Indometacine

C. Aspirin

D. Butadionum

E. Ibuprofen

9. The patient with fever was delivered to infectious unit. The nonopioid analgesic – derivative of salicylic acid is prescribed to patient. Indicate this drug.

*A. Acetylsalicylic acid

B. Analginum

C. Ibuprofen

D. Paracetamol

E. Diclophenac sodium

10. The patient with acute respiratory viruses disease and hyperthermia is delivered to infectious unit. What drug should be prescribed for decrease of temperature?

*A. Paracetamol

B. Ambroxol

C. Salbutamol

D. Adrenaline

E. Retabolil

11. For decreasing of possibility of gastric mucosa damage, the non-steroid anti-inflammatory agent - selective inhibitor of COX-2 is prescribed to patient with rheumatoid arthritis. Indicate this drug.

*A. Celecoxib

B. Analginum

C. Acetylsalicylic acid

D. Butadionum

E. Ibuprofen

10. Indicate a drug, the therapeutic effects of which are result of inhibition of prostaglandins synthesis.

*A. Acetylsalicylic acid

B. Fentanyl

C. Carbamazepine

D. Lithium salts

E. Morphine

11. A female consulted a doctor about pain and limited movements in the knee qoints. Which of the following nonsteroid antiinflammatory drugs should be administered taking into consideration that the patient has a history of chronic gastroduodenitis?

*A. Celecoxib

B. Promedolum

C. Butadione

D. Diclofenac sodium

E. Acetylsalicilic acid