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Файл:Oncology3.pdf
Primary Induction Chemotherapy
Cancers for which there are no other effective treatments
Advanced, metastatic diseases
Clinical end points:
àResponse rate: complete and partial response
àProgression-free survival
àOverall survival
Primary Induction Chemotherapy
Goals:
àCurative intent: chemotherapy-sensitive cancers
àPalliative intent
Primary Induction Chemotherapy:
Curative
Hodgkin’s disease
Non-Hodgkin’s lymphoma
Acute leukemia
Germ cell tumor
Curable childhood cancers:
àAcute lymphoblastic leukemia
àBurkitt’s lymphoma
àWilms’ tumor
àEmbryonal rhabdomyosarcoma
Primary Induction Chemotherapy
Palliative intent:
àPalliate tumor-related symptoms
àImprove overall quality of life
àProlong time to tumor progression
àProlong overall survival