Опухоли легких, плевры, тимуса и сердца ВОЗ

Mucoepidermoid carcinoma of the thymus 176

Mucosa-associated lymphoid tissue (MALT) lymphoma 225

Mucous cell adenoma 85 Mucous gland adenoma 85

Multifocal invasive adenocarcinomas 39 MUM1 138, 140, 224

Myasthenia gravis 120, 149, 196, 230 MYC (8q21-23) 22, 33, 34, 224, 228 Myelodysplastic syndromes (MDS) 197,

199, 201, 221, 240 Myeloid sarcoma 238 Myelolipoma 245

Myeloproliferative diseases 199, 219, 220

Myocardial or conduction system hamartoma 256

Myoepithelioma 67, 86 Myxoma, cardiac 260 Myxosarcoma 277

N

N-Acetyltransferases (NAT 1and 2) 24 NAME syndrome 262

Nasal-type NK/T-cell lymphoma 92 NAT2 24

Neonatal pulmonary hamartoma 102 Neuroblastoma 99, 200, 217, 245 Neuroendocrine carcinomas (NECs) of

the thymus 188 Neuroendocrine tumours 19 Neurofibromatosis 245

Naevoid basal cell carcinoma syndrome 269

NF kappa-B 137

NF2 tumour suppressor gene 135 Nicotine addiction 24, 25

NNK (tobacco specific nitrosamine) 15, 24

Nodular amyloidomas 90

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) 230 Nodular lymphoid hyperplasia (NLH) 88,

89

Nodular sclerosis Hodgkin lymphoma (NSHL) 230-233

Non-mucinous bronchioloalveolar carcinoma 35

Non-papillary adenocarcinomas of the thymus 184

Non-seminomatous germ cell tumours (NSGCT) 198

Non-small cell lung cancer (NSCLC) 1622, 29, 30, 33, 34, 44, 45, 47-50, 54, 62

Notch-1 oncogene 135

NPM gene on chromosome 5 231 NSCLC see Non-small cell lung cancer,

NSCLC with neuroendocrine differentiation (NSCLC-ND) 20

NSHL see Nodular sclerosis Hodgkin lymphoma

Nucleotide excision repair (NER) 22 NUT gene (nuclear protein in testis) 186

O

O6-Methylguanine DNA methyltransferase (MGMT) 22

Oat cell carcinoma 31 Occupational exposure 15

Old granulomatous disease 97, 98 Oncocytic cardiomyopathy 256 Oncocytic/oxyphilic carcinoid 192 Oncocytoma 86

Organizing pneumonia 58, 89 Organoid thymoma 159 Osteochondroma 101

Osteosarcoma 56, 57, 109, 133, 217, 245, 247, 277,284

Oxidative DNA damage 25

P

p14ARF 21, 34, 50, 62

p16 21, 29, 30, 43, 44, 70, 74, 75, 174, 224, 228, 232

p16INK4A methylation 71 p21WAF1 30, 44

p27 43 p27KIP1 30 p63 22, 30, 66 p80 106

PADPRP See Poly(ADP-ribose) polymerase

PAH See Polycyclic aromatic hydrocarbons

Pancoast tumour 26

Papillary adenocarcinoma 35, 38, 183 Papillary adenoma of type II pneumo-

cytes 84

Papillary carcinoma 26, 183

Papillary fibroelastoma of the heart 263 Papillary pneumocytoma 115 Papilloma 78

Papillomatosis 79 Paraganglioma 194, 245

Paraneoplastic symptoms 16, 183, 190 PAX3/FKHR fusion gene 242

PAX5 224

PC-1 224

PDGF receptor 110 PE-35 155 PEComa 118

PEH See Pleural epithelioid haemangioendothelioma

Peripheral papillary tumour of type II pneumocytes 84

Peripheral small cell carcinoma resembling carcinoid 19

Peutz-Jeghers syndrome 43 Phase I/II-xenobiotic metabolism 24 Pigmented carcinoid 192

PIK3CA gene (phosphatidylinositol-3 kinase subunit) 29

Pipe smoking 14

Placental alkaline phosphatase (PLAP) 182, 185, 203, 204, 206, 209, 212, 217

Plasma cell granuloma 89, 105, 270 PLCH See Pulmonary Langerhans cell

histiocytosis Pleomorphic adenoma 86

Pleomorphic carcinoma 53, 55, 58 Pleomorphic malignant fibrous histiocy-

tomaof the heart 276

Pleural epithelioid haemangioendothelioma (PEH) 97, 98, 141

Pleural pseudomyxoma 87 Pleuropulmonary blastoma 99 Plombage therapy for tuberculosis 129 PMLBCL See Primary mediastinal large

B-cell lymphoma

PNC See Pulmonary neuroendocrine cells 76, 77

Pneumocytoma 115

Polyadenoma 85

Polycyclic aromatic hydrocarbons 15, 22, 23, 24

Polyembryoma 213, 214

Poorly differentiated neuroendocrine carcinomas 188

Poorly differentiated neuroendocrine thymic carcinomas 193

Poorly-differentiated lymphocytic lymphoma 227

Precursor T-cell acute lymphoblastic leukaemia (ALL) 227

Precursor T-cell lymphoblastic lymphoma (LBL) 227

Precursor T-lymphoblastic lymphoma/ leukaemia 227

Predominantly cortical thymoma 159 Primary cardiac lymphoma 282 Primary effusion lymphoma 137 Primary mediastinal (thymic) large B-cell

lymphoma 222

Primary mediastinal clear cell lymphoma of B-cell type 222

Primary mediastinal large B-cell lymphoma (PMLBCL) 221, 222, 224, 232, 233

Primitive neuroectodermal tumours (PNET) 33, 217

PRKAR1A gene 263

Promoter hypermethylation 21, 22

Pseudoangiosarcomatous carcinoma 55 Pseudosarcomatous myofibroblastic

tumour 105

PTC gene (9q22.3) 269 Pulmonary artery sarcoma 109 Pulmonary blastoma 53, 56

Pulmonary blastoma associated with cystic lung disease 99

Pulmonary blastoma of childhood 99 Pulmonary eosinophilic granuloma, 95,

235

Pulmonary epithelioid haemangioendothelioma (PEH) 97

Pulmonary hamartoma (mesenchymoma) 101

Pulmonary histiocytosis X 95 Pulmonary Langerhans cell granulomato-

sis 95

Pulmonary Langerhans cell histiocytosis 95, 96

Pulmonary MALT lymphoma 88-90 Pulmonary neuroendocrine cells (PNCs)

76, 77

Pulmonary pleomorphic adenoma 86 Pulmonary sarcoma arising in mesenchy-

mal cystic hamartoma 99 Pulmonary synovial sarcoma 111 Pulmonary vein sarcoma 108

Pure red cell aplasia 153, 154, 157, 159, 161, 164, 171, 172, 183, 196

Purkinje cell hamartoma 256, 257, 258

Pyothorax-associated lymphoma 138

R

RAR-beta 30, 34, 70

RAS family of oncogenes 21, 43, 44, 50, 52, 72, 74, 224, 275, 279

RASSF1 21, 30, 34, 62, 135 Rb protein 21, 74

RB1 gene 21, 29, 30, 34, 62, 71, 79, 156, 165, 277

RBTN2 (11q13) 228

Rearrangement of T-cell receptor genes 138

REL-protooncogene (2p15) 232 Rhabdoid phenotype, carcinoma with 45,

46, 48

Rhabdomyoma 245, 254, 255, 256, 258, 259, 270

Rhabdomyoma of the heart 254 Rhabdomyomatosis 254, 258 Rhabdomyosarcoma 242, 259, 278, 279 Rhabdomyosarcoma (RMS) of the thy-

mus 242

Rhabdomyosarcoma of the heart 278 Rhabdomysarcoma arising in congenital cystic adenomatoid malformation 99

Roberts syndrome SC phocomelia syndrome (RS) 267

S

SAGE see Serial analysis of gene expression

Salivary gland tumours 63 Sarcoidosis 89, 196 Sarcoma botryoides 279

Sarcomatoid carcinoma 53, 179-181 Sarcomatoid mesothelioma 128, 133 Sarcomatous mesothelioma of the peri-

cardium 285 SAS/CDK4 110

Schiller-Duval bodies 206, 207 Schwannoma 245, 262 Schwartz-Bartter syndrome 16 SCLC see Small cell lung cancer Sclerosing haemangioma 84, 115 Sclerosing thymoma 171

SCNEC See Small cell neuroendocrine carcinoma

SEMA3B 21

Semaphorin 3B (secreted semaphorin) 21

Seminoma 182, 198, 2199, 202-206, 209, 214, 223, 287, 288

Serial analysis of gene expression (SAGE) 30, 43

SFT See Solitary fibrous tumour 142, 143, 241, 242

Signet ring adenocarcinoma 35, 40 Small cell anaplastic carcinoma 31 Small cell carcinoma (SCC) 26, 31, 32,

49, 187-189, 193

Small cell carcinoma of the lung 31 Small cell carcinoma, neuroendocrine

type 189

Small cell lung carcinoma (SCLC) 16-22, 29-34, 45, 49, 50, 61, 62, 72

Small cell neuroendocrine carcinoma 191, 193

Small round blue cell tumours (SRBCT) 33

Smoking cessation 14, 71, 96 Solid adenocarcinoma 35, 39

Solitary fibrous tumour (SFT) 142, 143, 241, 242, 285

Solitary fibrous tumour of the thymus 241

Solitary fibrous tumour of the pericardium 285

Solitary fibrous tumour of the pleura 142 Sotos syndrome 259

Sox6 gene (p100H) 258 Spider cells 255

Spindle cell carcinoid 180, 191 Spindle cell carcinoma 53, 55

Spindle cell thymoma 154 Spiral CT 26

Sputum cytology 17, 19, 68

Squamous cell carcinoma 21, 26-29, 68, 79, 172, 173

Squamous cell papilloma 78 Squamous dysplasia, lung 68 SS18/SSX transcripts 281

SSX1 / SSX2 gene (chromosome X) 112 Struma ovarii 209

Submesothelial fibroma 285

Sudden infant death syndrome (SIDS) 256

ʻSugar tumourʼ in the lung 118 Surfactant apoprotein 40, 57, 74, 84,

116, 183 Surfactant-associated protein A 87 Sustentacular cells 61, 194, 245 SV40 129, 135

Syncytiotrophoblast 119, 206, 209, 214 Synovial sarcoma 111, 141, 142, 181,

244, 280

Synovial sarcoma of the thymus 244 Synovial sarcoma of the heart 280 Synovioblastic sarcoma 111, 141 SYT gene on chromosome 18 112

SYT-SSX chimeric RNA transcripts 244 SYT-SSX2 gene fusion 181

T

t(11;18)(q21;q21) translocation 90 TAL1 locus at 1p32 228

Tar (tobacco) 14, 24 Tawarian node 272

T-cell acute lymphoblastic leukaemia 227

T-cell lymphoblastic lymphoma 227 T-cell receptor (TCR) gene rearrange-

ment 228 Teratocarcinoma 213

Teratoma 99, 119, 123, 198-202, 205, 206, 208-214, 216, 218, 287

Teratoma with malignant transformation 216

Teratoma with non-germ cell malignancy 216

Teratoma with somatic-type malignancy 209

Teratoma of the thymus 210

Terminal deoxynucleotidyl transferase (TdT) 228

Testicular cancers 199 Therapeutic radiation 129, 286 Thrombocytemia 219

Thymic epithelial tumours 150, 188 Thymic epithelial tumours 152 Thymic MALT lymphoma 225 Thymic neuroendocrine tumours 188

Thymic squamous cell carcinoma 172 Thymolipoma 239

Thymolipomatous hamartoma 239 Thymoma (type X) 152 Thymoma type A 154

Thymoma with pseudosarcomatous stroma 169

Thyroid transcription factor 1 (TTF-1) 41 TIE2 gene /Bean or “Blue rubber-bleb

nevus” syndrome 267

Tissue inhibitor of metalloproteinase (TIMP) 70

Tobacco smoking 12, 14, 15, 53, 88 Tobacco specific nitrosamine 24 Topoisomerase alpha II 79 Transcription factor YB-1 30 Transitional papillomas 81 Translocation t(8;13) 228 Trichoptysis 119

Trisomy 3 90 Triton tumours 245

True histiocytic lymphoma 235

TSC1/2 (tuberous sclerosis genes) 75, 107, 108, 256

TSG tumour suppressor gene 34

TTF-1 28, 32, 33, 40-42, 47, 48, 51, 57, 61, 74, 82, 84, 111, 116, 124, 133, 193, 194

Tuberous sclerosis complex (TSC) 107

Type A thymoma 152, 154, 155, 165, 182

Type AB thymoma 157, 158, 170, 196 Type B1 thymoma 159

Type B2 thymoma 161, 163 Type B3 thymoma 164, 197 Type I/II cells 41

Type II pneumocyte adenoma 84

Type II pneumocytes 42, 43, 58, 74, 79, 84, 115, 116

Typical (classic) carcinoid 189 Typical carcinoid 19, 59, 191

U

Undifferentiated carcinoma of the thymus 187

Undifferentiated pleomorphic sarcoma 276

Undifferentiated small cell carcinoma 31

V

Videothoracoscopy 130

Viral IL-6 (vIL-6) 137

Von Hippel Lindau disease 266 Von Willebrand factor 97, 141, 274

W

Waldenstrom macroglobulinemia 88 Weibel-Palade bodies 98

Well differentiated neuroendocrine carcinoma 59, 188

Well differentiated papillary mesothelioma 135

Well-differentiated neuroendocrine carcinoma 19

Wiskott-Aldrich syndrome 92

Wolf Parkinson White syndrome 256, 258

WT1-EWS gene fusion 144

X

XPD (xeroderma pigmentosum D) 24 Xq amplification 224

XRCC1 (base excision repair gene) 24

Y

Yolk sac tumour (YST) 184, 198-200, 205, 206, 207-209, 212-214, 220, 287